Pharmacology, Biochemistry, and Behavior
May 1981
Randall L. Commissaris, William H. Lyness, K E Moore et al.
The present study was designed to examine the role of 5-hydroxytryptamine (5-HT) neurons in the behavioral effects of d-lysergic acid diethylamide (LSD), an indolealkylamine hallucinogen, 2.5-dimethoxy-4-methylamphetamine (DOM) and mescaline, phenethylamine hallucinogens, and phenobarbital, a non-hallucinogen. Male rats, maintained at 70-80% of their free-feeding weights, were trained to press...
Pharmacology, Biochemistry, and Behavior
May 1, 1981
Randall L. Commissaris, William H. Lyness, Richard H. Rech
29 citations
The purpose of the present study was to determine the role of central 5-hydroxytryptamine (5-HT) neuronal systems in the effects of d-lysergic acid diethylamide (LSD), 2,5-methoxy-4-methylamphetamine (DOM), pentobarbital (PB) and methaqualone (MQ) on punished responding in rats. Water-deprived rats were trained to drink from a tube that was electrified at intervals (variable interval 21 sec;...
Journal of Abnormal Psychology
February 1, 1981
Timothy J. Hoelscher, Eric Klinger, Steven G. Barta
90 citations
The hypothesis that cues related to subjects ' current concerns can control attentional and cognitive processes during sleeping and dreaming was examined by presenting concern- and nonconcern-related verbal stimuli to seven male subjects during sleep Stages 2 and REM. The taped dream reports were judged for stimulus incorporation by two independent raters. The results revealed that concern...
Journal of Pharmacobio-Dynamics
1981
Kazuko Kawanishi, Yôhei Hashimoto, Michihiro Fujiwara et al.
11 citations
Harmine, a hallucinogen with potent monoamine oxidase inhibitory properties, induced abnormal behavior, including tremor, scratching, head twitch and cage biting, in the mouse. A dose-dependent tremor was produced by all routes of administration of harmine. Although oxotremorine tremor was markedly suppressed by atropine, harmine tremor was unaffected by cholinergic drugs, remarkably inhibited...
Psychopharmacology
1981
D M Ruffing, E F Domino
Several opioid agonists and antagonists interact with N,N-dimethyltryptamine (DMT) and lysergic acid diethylamide-25 (LSD) in adult male Holtzman rats trained on a positive reinforcement, fixed ratio 4 (FR4) behavioral schedule, i.e., a reward of 0.01 ml sugar-sweetened milk was earned on every fourth bar press. DMT (3.2 and 10.0 mg/kg) and LSD (0.1 mg/kg) given IP with 0.9% NaCl pretreatment,...
Pharmacology, Biochemistry, and Behavior
1981
R F Schlemmer, J M Davis
31 citations
Evidence gathered from several experiments where stimulant drugs were given to selected members of adult Stumptail macaque social colonies is presented which suggests that dopamine systems play an important part in the mediation of submissive behavior in this species. Chronic administration of d-amphetamine, 3.2 mg/kg/day, for 12 days, induced a significant increase in submissive gestures...
Postgraduate medicine
November 1980
M S Beede
Phencyclidine (PCP) is a dissociative anesthetic whose abuse is a growing problem. Historically, its effects have been considered remarkably like those of the schizophrenic state, but in vitro and in vivo neuropharmacologic data are somewhat inconsistent with the dopaminergic hypothesis of schizophrenia. The physiologic and psychiatric manifestations of PCP intoxication are diverse and somewhat...
Pharmacology, Biochemistry, and Behavior
November 1980
Randall L. Commissaris, William H. Lyness, J J Cordon et al.
The purpose of the present study was to determine the role of central catecholaminergic neuronal systems in the effects of LSD, DOM and d-amphetamine on fixed ratio (FR) operant responding in rats. Food-deprived male rats were trained to press a bar for food reinforcement on a FR-40 schedule. Control responding on this schedule is characterized by a rapid, constant rate of responding...
British Journal of Pharmacology
November 1, 1980
V. P. Poshivalov
23 citations
Mice in small groups develop a despotic type of social hierarchy, a feature of which is to resist alteration through the medium of psychotropic drugs. This makes a rapid pharmacologically induced change in the social hierarchy impossible. Patrolling the territory and a certain level of social interaction are both critical factors in maintaining the phenomenon of inertia in the social hierarchy....
Pharmacology, Biochemistry, and Behavior
October 1980
Torbjörn U C Järbe
Pigeons (N=4) were trained to discriminate between the effects induced by intramuscular (IM) injections of d-LSD and saline using a discrete-trial discrimination paradigm (choice between left and right hand key) in a conventional operant box. The solutions were administered IM 15 min prior to the sessions. A FR 15 schedule was in operation to produce food. Which of the two keys was correct on a...