Journal of Pharmacobio-Dynamics
1981
Kazuko Kawanishi, Yôhei Hashimoto, Michihiro Fujiwara et al.
11 citations
Harmine, a hallucinogen with potent monoamine oxidase inhibitory properties, induced abnormal behavior, including tremor, scratching, head twitch and cage biting, in the mouse. A dose-dependent tremor was produced by all routes of administration of harmine. Although oxotremorine tremor was markedly suppressed by atropine, harmine tremor was unaffected by cholinergic drugs, remarkably inhibited...
Psychopharmacology
1981
D M Ruffing, E F Domino
Several opioid agonists and antagonists interact with N,N-dimethyltryptamine (DMT) and lysergic acid diethylamide-25 (LSD) in adult male Holtzman rats trained on a positive reinforcement, fixed ratio 4 (FR4) behavioral schedule, i.e., a reward of 0.01 ml sugar-sweetened milk was earned on every fourth bar press. DMT (3.2 and 10.0 mg/kg) and LSD (0.1 mg/kg) given IP with 0.9% NaCl pretreatment,...
Pharmacology, Biochemistry, and Behavior
1981
R F Schlemmer, J M Davis
31 citations
Evidence gathered from several experiments where stimulant drugs were given to selected members of adult Stumptail macaque social colonies is presented which suggests that dopamine systems play an important part in the mediation of submissive behavior in this species. Chronic administration of d-amphetamine, 3.2 mg/kg/day, for 12 days, induced a significant increase in submissive gestures...
Postgraduate medicine
November 1980
M S Beede
Phencyclidine (PCP) is a dissociative anesthetic whose abuse is a growing problem. Historically, its effects have been considered remarkably like those of the schizophrenic state, but in vitro and in vivo neuropharmacologic data are somewhat inconsistent with the dopaminergic hypothesis of schizophrenia. The physiologic and psychiatric manifestations of PCP intoxication are diverse and somewhat...
Pharmacology, Biochemistry, and Behavior
November 1980
Randall L. Commissaris, William H. Lyness, J J Cordon et al.
The purpose of the present study was to determine the role of central catecholaminergic neuronal systems in the effects of LSD, DOM and d-amphetamine on fixed ratio (FR) operant responding in rats. Food-deprived male rats were trained to press a bar for food reinforcement on a FR-40 schedule. Control responding on this schedule is characterized by a rapid, constant rate of responding...
British Journal of Pharmacology
November 1, 1980
V. P. Poshivalov
23 citations
Mice in small groups develop a despotic type of social hierarchy, a feature of which is to resist alteration through the medium of psychotropic drugs. This makes a rapid pharmacologically induced change in the social hierarchy impossible. Patrolling the territory and a certain level of social interaction are both critical factors in maintaining the phenomenon of inertia in the social hierarchy....
Pharmacology, Biochemistry, and Behavior
October 1980
Torbjörn U C Järbe
Pigeons (N=4) were trained to discriminate between the effects induced by intramuscular (IM) injections of d-LSD and saline using a discrete-trial discrimination paradigm (choice between left and right hand key) in a conventional operant box. The solutions were administered IM 15 min prior to the sessions. A FR 15 schedule was in operation to produce food. Which of the two keys was correct on a...
Pharmacology, Biochemistry, and Behavior
October 1, 1980
Randall L. Commissaris, K.E. Moore, Richard H. Rech
8 citations
Food-deprived male rats were trained to press a lever on a fixed ratio-40 (FR-40) operant schedule for food reinforcement. Administration of mescaline (4.0--10.0 mg/kg) immediately before the start of the operant session resulted in a cessation of responding for some portion of the 40-min period ("hallucinatory pause"). The duration of this pause was found to be dose-dependent. Although...
Journal of Pharmacology and Experimental Therapeutics
September 1, 1980
S. Holtzman
Possible commonalities in the discriminative stimulus properties of phencyclidine (PCP) and opioids were investigated in rats trained to discriminate between i.p. injections of saline and 2.0 mg/kg of PCP in a two-choice discrete-trial avoidance paradigm. Behavior was considered to be under stimulus control when a rat reliably completed at least 18 trials of a 20-trial session on the...
Fortschritte der Neurologie · Psychiatrie
June 1, 1980
M. Koukkou, Dietrich Lehmann
27 citations
The paper presents a functional model of the brain; this model uses psychophysiological mechanisms to explain dream formation, without postulating specific dream processes; the same mechanisms serve to explain neurotic thinking (the basis of neurotic behaviour), and its psychotherapeutic correction. The description of the model includes a synopsis of selected publications from the fields of...