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Andrew J. Lees

6 papers in the library · 108 citations · publishing 1979-2025

Papers

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Voluntary and involuntary motor behaviours in the varieties of religious experience.

Brain Communications 2025 Christos Ganos, Michael A Ferguson, Kurt Gray et al.

Religion is a widespread feature of human life. Religions typically include both distinctive varieties of experience and also a set of foundational beliefs. An additional, but often overlooked, part of many religions is their expression through specific actions, which we here designate religious motor behaviours. Here we describe these religious motor behaviours and offer a taxonomy based on...

Changes in dynamic transitions between integrated and segregated states underlie visual hallucinations in Parkinson’s disease

Communications Biology September 8, 2022 Angeliki Zarkali, Andrea I. Luppi, Emmanuel A. Stamatakis et al.

Hallucinations are a core feature of psychosis and common in Parkinson’s. Their transient, unexpected nature suggests a change in dynamic brain states, but underlying causes are unknown. Here, we examine temporal dynamics and underlying structural connectivity in Parkinson’s-hallucinations using a combination of functional and structural MRI, network control theory, neurotransmitter density and...

21 Psychedelic treatment of functional neurological disorder – a systematic review

Journal of Neurology Neurosurgery & Psychiatry July 20, 2020 Matthew Butler, Mathieu Seynaeve, Timothy R. Nicholson et al.

Aims Functional neurological disorder (FND), formerly known as conversion disorder, causes a high burden of disability and distress, and is amongst the most commonly encountered conditions in neurology clinics and neuropsychiatry services, yet the therapeutic evidence base is limited. Research into psychedelics such as psilocybin and lysergic acid diethylamide (LSD) is currently being...

Psychedelic treatment of functional neurological disorder: a systematic review

Therapeutic Advances in Psychopharmacology 2020 Matthew Butler, Mathieu Seynaeve, Timothy R. Nicholson et al. 38 citations

Functional neurological disorder (FND), formerly known as conversion disorder, causes a high burden of disability and distress, and is amongst the most commonly encountered conditions in neurology clinics and neuropsychiatric services, yet the therapeutic evidence base is somewhat limited. There has been recent interest in the therapeutic potential of psychedelics such as psilocybin and...

William Burroughs: Sailor of the Soul

Journal of Psychoactive Drugs August 10, 2017 Andrew J. Lees 4 citations

In 1953, William Seward Burroughs made several important and largely unrecognized discoveries relating to the composition and clinical pharmacological effects of the hallucinogenic plant potion known as yagé or ayahuasca. Illustrations of Burroughs' voucher sample of Psychotria viridis and his letter to the father of modern ethnobotany, Richard Evans Schultes, are published here for the very...

BACKWARD WALKING AND CIRCLING: BEHAVIOURAL RESPONSES INDUCED BY DRUG TREATMENTS WHICH CAUSE SIMULTANEOUS RELEASE OF CATECHOLAMINES AND 5‐HYDROXYTRYPTAMINE

British Journal of Pharmacology August 1, 1979 G. Curzon, J.c.r. Fernando, Andrew J. Lees 66 citations

The roles of catecholamine and 5‐hydroxytryptamine (5‐HT) release in mediating backward walking and circling were studied in rats. These behaviours occurred in animals given 15mg/kg intraperitoneally of (+)‐amphetamine (which predominantly releases catecholamines) or either p ‐chloroamphetamine or fenfluramine (which predominantly release 5‐HT). They also occurred when smaller doses of...