Journal of Psychopharmacology
May 14, 2019
Albert Garcia‐romeu, Alan K. Davis, Fire Erowid et al.
286 citations
Background: Meta-analysis of randomized studies using lysergic acid diethylamide (LSD) for alcohol use disorder (AUD) showed large, significant effects for LSD efficacy compared to control conditions. Clinical studies suggest potential anti-addiction effects of LSD and mechanistically-related classic psychedelics for alcohol and other substance use disorders. Aims: To supplement clinical...
Drug Testing and Analysis
May 13, 2019
Simon D. Brandt, Pierce V. Kavanagh, Folker Westphal et al.
72 citations
Abstract The psychedelic properties of lysergic acid diethylamide (LSD) have captured the imagination of researchers for many years and its rediscovery as an important research tool is evidenced by its clinical use within neuroscientific and therapeutic settings. At the same time, a number of novel LSD analogs have recently emerged as recreational drugs, which makes it necessary to study their...
Frontiers in Neurology
May 9, 2019
Tirza Naarden, Bastiaan C. Ter Meulen, Sarah I Van der Weele et al.
Background: Alice in Wonderland syndrome (AIWS) is a rare neurological disorder characterized by distortions of visual perception (metamorphopsias), the body image, and the experience of time, along with derealization and depersonalization. Some 85% of patients present with perceptual distortions in a single sensory modality, e.g., only visual or only somesthetic in nature. Moreover, the...
JURNAL KEPERAWATAN
May 2, 2019
Rahel A. Kululu, Esrom Kanine, Andi Buanasari
Abstrack: The use of narcotics, psychotropic and other addictive substances hasbeen used up to adolescents. Adolescents use drugs because it has many motivation, motivation arising from within themselves as well as the motivation that arise because of the encouragement from the outside.The use of this drug can also be seen in Johnson's behavioral system model by reviewing with seven subsystems....
Physiology & Behavior
May 1, 2019
Kristofer J Schoepfer, Caroline E. Strong, Samantha K Saland et al.
Subanesthetic ketamine (KET) elicits rapid, robust, but transient antidepressant effects. KET's antidepressant actions can be augmented and maintained for a longer duration when repeatedly delivered. However, KET is recreationally abused, raising long-term treatment safety concerns. Women are more likely than men to seek treatment for depression, escalate from casual to compulsive drug use, and...
The Journal of Speculative Philosophy
May 1, 2019
Íngrid Vendrell Ferran
ABSTRACT: This article argues that religious emotions are variations of general emotions that we already know from our everyday life, which nevertheless exhibit specific features that enable us to think of them as forming a coherent subclass. The article claims that there is an experience of joy, sorrow, regret, fear, and so on that is specifically religious. The aim is to develop an account...
Neuroscience Letters
May 1, 2019
Han-Gue Jo, José R. Naranjo, Thilo Hinterberger et al.
Neuronal interactions coupled by phase synchronization have been studied in a wide range of frequency bands, but fluctuations below the delta frequency have often been neglected. In the present study, phase synchrony in slow cortical potentials (SCPs, 0.01-0.1 Hz) was examined during two different mental states; a resting state and a breath-focused mindfulness meditation. SCP phase synchrony in...
Journal of Pharmacology and Experimental Therapeutics
May 2019
Benjamin M Ford, Christian V Cabanlong, Sherrica Tai et al.
Most cannabinoid 1 receptor (CB1R) agonists will signal through both G protein-dependent and -independent pathways in an unbiased manner. Recruitment of β-arrestin 2 desensitizes and internalizes receptors, producing tolerance that limits therapeutic utility of cannabinoids for chronic conditions. We developed the indole quinuclidinone (IQD) analog...
Neurotoxicity Research
May 1, 2019
Peng Xu, Qiyang Qiu, Haijie Li et al.
25C-NBOMe is a designer substituted phenethylamine and a high-potency psychedelic that acts on the 5-HT2A receptor. Although 25C-NBOMe overdoses have been related to several deaths in the USA and Europe, very limited data exists on the in vitro neurotoxicity of 25C-NBOMe. In this study, we found that 25C-NBOMe potently reduced cell viability of SH-SY5Y, PC12, and SN4741 cells, with IC50 values...
Clinical EEG and Neuroscience
May 1, 2019
Shirley Telles, Deepeshwar Singh, Kv Naveen et al.
Sympathetic activation is required for attention. Separate studies have shown that meditation ( a) improves attention and ( b) reduces sympathetic activity. The present study assessed attention with the P300 and sympathetic activity with heart rate variability (HRV). Forty-seven male subjects (group mean age ± SD, 21.6 ± 3.4 years) were assessed in 4 mental states: ( a) random thinking, ( b)...