The mystical experience is a potential psychological mechanism to influence outcome in psychedelic therapy. It includes features such as oceanic boundlessness, ego dissolution, and universal interconnectedness, which have been closely linked to both symptom reduction and improved quality of life. In this review, 12 studies of psychedelic therapy utilizing psilocybin, ayahuasca, or ketamine were...
Consciousness is supported by complex patterns of brain activity which are indicative of irreversible nonequilibrium dynamics. While the framework of stochastic thermodynamics has facilitated the understanding of physical systems of this kind, its application to infer the level of consciousness from empirical data remains elusive. We faced this challenge by calculating entropy production in a...
Abstract Psilocybin is a tryptamine alkaloid found in some mushrooms, especially those of the genus Psilocybe. Psilocybin has four metabolites including the pharmacologically active primary metabolite psilocin, which readily enters the systemic circulation. The psychoactive effects of psilocin are believed to arise due to the partial agonist effects at the 5HT2A receptor. Psilocin also binds to...
Consciousness is supported by complex patterns of brain activity which are indicative of irreversible non-equilibrium dynamics. While the framework of stochastic thermodynamics has facilitated the understanding of physical systems of this kind, its application to infer the level of consciousness from empirical data remains elusive. We faced this challenge by calculating entropy production in a...
This is the third of three related articles. The first one (Tóth-Izsó & Lombard, 2022a) presents the two authors’ English translations of the Italian poem indicated in the title and compares them depending on the translators’ experiences before and during the translation. It is also shown how the resultant translations are determined both by the salient features of the source text and by the...
Abstract This chapter considers the ontological implications of encountering varying levels of intelligibility when one traverses social structures, such as when one immigrates to a new culture or works in a place with people of a different economic class than one’s own. This chapter terms this phenomenon “world-traveling,” which the chapter understands as the shift in self-experience that...
Frontiers in PsychologyJuly 7, 2022Jesús M. Siqueiros-García, David Manuel‐navarrete, Hallie Eakin et al.7 citations
In the last few years, there has been an interest in understanding the impact of environmental change and degradation on people's affective life. This issue has become particularly pressing for populations whose form of life is heavily dependent on ecosystem services and functions and whose opportunities for adaptation are limited. Based on our work with farmers from the Xochimilco urban...
Abstract This is a narrative review about the role of classic and two atypical psychedelics in the treatment of unipolar and bipolar depression. Since the 1990s, psychedelics experience a renaissance in biomedical research. The so-called classic psychedelics include lysergic acid diethylamide (LSD), psilocybin, mescaline and ayahuasca. Characteristic effects like alterations in sensory...
Abstract Objectives This study attempts to assess the concentration of two opposite-acting adipokines (anti-inflammatory adiponectin and pro-inflammatory resistin) in antidepressant-resistant patients undergoing ketamine infusion (KI) and electroconvulsive therapy (ECT). Methods The study group comprised 52 patients hospitalised due to episodes of depression in the course of bipolar disorders....
The present paper is concerned with a qualitative, analytical, and comparative method of exploring Buddhist perspectives on phenomenal consciousness. The phenomenal consciousness sciences have offered a mechanical explanation of the ‘how’ and ‘what’ of consciousness, but have failed to explain the ‘why’ of consciousness. The Buddhists have given a systematic explanation of conscious experience...