ABSTRACT The effects of cannabis reported by users range from experiences of euphoria and anxiolytic effects to paranoia, anxiety, and increased risk of depression. Attempts to reconcile the apparent contradictions in user response have not been conclusive. Here, we utilized selectively-bred stress-resilient socially dominant (Dom) and stress-sensitive socially submissive (Sub) mice to...
Memories are not frozen in the past. Instead, they can be dynamically combined to allow individuals to adapt to the present or even imagine the future. This recombination, called event construction, also means that it might be possible to improve memory through specific interventions such as episodic specificity induction (ESI). ESI provides brief training in recollecting the details of a past...
While physicalism requires only that a conscious state depends entirely on an underlying physical state, it is often assumed that consciousness is algorithmic and that conscious states can be copied, such as by copying or digitizing the human brain. In an effort to further elucidate the physical nature of consciousness, I challenge these assumptions and attempt to prove the Single Stream of...
Objective: The purpose of the present study was to obtain patient information across a wide geography about medical history, drug use, symptoms, and treatments of individuals diagnosed with hallucinogen persisting perception disorder (HPPD). Methods: The study was an internet survey that yielded 26 HPPD patients from North America (81%), Europe (12%), and South America (almost 8%),...
Ayahuasca is a botanical hallucinogenic preparation traditionally used for ritual and therapeutic purposes by native populations of the Northwestern Amazon. In the last decades, ayahuasca use has spread to Europe, the United States, Asia, and Africa, and interest in the possible therapeutic uses of ayahuasca for treating anxiety and mood disorder and substance-use disorders has increased both...
Abstract: Our great ape cousins, and very likely the last common ancestor of the human and pan lineage, depend very largely on their own intrinsic capacities not just for material resources but also for their informational resources. Chimps and bonobos are capable of social learning, and very likely, in their foraging and their communicative practices, they do learn from their parents and...
A subanesthetic dose of ketamine causes acute psychotomimetic symptoms and sustained antidepressant effects. In prefrontal cortex, the prevailing disinhibition hypothesis posits that N-methyl-d-aspartate receptor (NMDAR) antagonists such as ketamine act preferentially on GABAergic neurons. However, cortical interneurons are heterogeneous. In particular, somatostatin-expressing (SST)...
The recreational drug 3,4-methylenedioxymethamphetamine (MDMA) has well documented prosocial effects and is currently under clinical investigation as a treatment for patients with PTSD, autism, and other conditions. Early clinical trials have found that MDMA-assisted therapy may have robust long-lasting therapeutic effects, yet the mechanism by which acute treatments produce these long-term...
EmotionJune 1, 2019Alon Alkoby, Ruthie Pliskin, E. Halperin et al.
Individuals encounter a variety of emotional challenges daily, with optimal emotion modulation requiring adaptive choice among available means of regulation. However, individuals differ in the ability to flexibly and adaptively move between engaging and disengaging emotion regulation (ER) strategies as per contextual demands, referred to as regulatory choice flexibility. Greater regulatory...
Introduction: The survey of drug and psychedelic abuse-related deaths in elderly people provides information on the most severe social and psychological consequences of drug abuse and its impact on community health. In contrast, with regard to the ageing population of Iran, along with all age groups who might misuse drugs, elderly people cannot be ignored. Therefore, the present study aims to...