Current Neuropharmacology
June 30, 2026
Jiaying Wang, Rui Zhang, Yuanyuan Ma et al.
Ketamine and its structural analog, 2-Fluorodeschloroketamine, both potent stimulants, can induce euphoria but also cause neurotoxicity, cognitive decline, and neurodevelopmental deficits in the fetus. However, the molecular mechanisms responsible for these neurodevelopmental abnormalities are not yet fully elucidated, particularly concerning effects that are specific to certain cell types....
Ingegneria Sismica
June 10, 2026
Peng Xu
Objective: This study aimed to examine the effects of a Mindfulness-Based Community Renewal (MBCR) intervention on residents’ mindfulness, empathy, and sense of community within an urban renewal context. Methods: Fifty community residents were randomly assigned to either an experimental group receiving four biweekly mindfulness workshops over eight weeks or a control group receiving standard...
Behavioural Pharmacology
July 7, 2025
Kaixi Li, Nan Li, Yuanyuan Chen et al.
Alpha-methyltryptamine (AMT), 5-methoxy-alpha-methyltryptamine (5-MeO-AMT), and 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DiPT) are synthetic tryptamines with hallucinogenic-like properties that are widely abused worldwide. There, however, has been a paucity of research and a lack of available data on their pharmacological properties. The objective of this study was to investigate the safety...
Neuroscience Research
July 1, 2025
Kaixi Li, Nan Li, Yuanyuan Chen et al.
1 citation
Alpha-methyltryptamine (AMT), 5-methoxy-alpha-methyltryptamine (5-MeO-AMT), and 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DiPT) are three synthetic tryptamines with hallucinogenic properties that are widely abused worldwide. The hallucinogenic effects of tryptamines are primarily related to activation of the 5-HT receptor, and among the many subtypes of 5-HT receptors, the 5-HT2A receptor is...
Psychophysiology
June 1, 2025
Yanfen Zhen, Pei Liu, Lin Jiang et al.
2 citations
Nonsuicidal self-injury (NSSI) is a recurring behavior most prevalent among adolescents in which one intentionally harms one's tissues and organs without the intent of death, which has a complex pathophysiology and lacks established interventions. As NSSI has been linked to deficits in cognitive control, mindfulness training that enhances this process may be beneficial. In this study, using...
Fa yi xue za zhi
February 25, 2024
Wei-Guang Yu, Qiang He, Zheng-Di Wang et al.
To investigate the toxicokinetic differences of 3,4-methylenedioxy-N-methylamphetamine (MDMA) and its metabolite 4,5-methylene dioxy amphetamine (MDA) in rats after single and continuous administration of MDMA, providing reference data for the forensic identification of MDMA. A total of 24 rats in the single administration group were randomly divided into 5, 10 and 20 mg/kg experimental groups...
Psychopharmacology
June 1, 2023
Zi-Hang Tang, Zhi-Peng Yu, Qiong Li et al.
7 citations
Serotonergic psychedelics show promise in the treatment of psychiatric disorders, including obsessive-compulsive disorder. Dysfunction of the orbitofrontal cortex (OFc) has been implicated in the pathophysiology of compulsive behavior, which might be a key region for the efficacy of psychedelics. However, the effects of psychedelics on the neural activities and local excitation/inhibition (E/I)...
Neuropharmacology
April 1, 2023
Zhi-Peng Yu, Qiong Li, Zhou-Xiao Wu et al.
7 citations
Serotoninergic psychedelics induced extensive alterations in perception and cognition, which has been attributable to its disruptive effect on oscillatory rhythms of prefrontal cortex. However, there is a lack of information how serotoninergic psychedelics affect the intra-prefrontal network, which intrinsically interact to accomplish perceptual processing. Uncovering the altered neural network...
Addiction Biology
May 1, 2022
Feng Li, Han Du, Bo Wu et al.
16 citations
2-Fluorodeschloroketamine (2-FDCK) as a substitute for ketamine has emerged among drug abusers in recent years. However, 2-FDCK has not been controlled or regulated in many countries, which may be partly related to the lack of evidence on its abuse potential. In this study, we evaluated the abuse potential of 2-FDCK via the tests of the conditioned place preference (CPP), locomotor...
Neurotoxicity Research
May 1, 2019
Peng Xu, Qiyang Qiu, Haijie Li et al.
25C-NBOMe is a designer substituted phenethylamine and a high-potency psychedelic that acts on the 5-HT2A receptor. Although 25C-NBOMe overdoses have been related to several deaths in the USA and Europe, very limited data exists on the in vitro neurotoxicity of 25C-NBOMe. In this study, we found that 25C-NBOMe potently reduced cell viability of SH-SY5Y, PC12, and SN4741 cells, with IC50 values...
Clinical Neurophysiology
June 15, 2010
Yun Qin, Peng Xu, Dezhong Yao
207 citations
ObjectiveThe choice of electroencephalograph (EEG) reference is a critical issue for the study of brain activity. The present study addressed the use of the infinity reference obtained by the reference electrode standardisation technique (REST) in the study of EEG default mode network (DMN).MethodsA total of 100 randomly positioned source configurations, each consisting of two dipoles with...