bioRxiv
June 3, 2026
Camilo Espinosa-Curilem, L. Uhrig, Jordie Tasserie et al.
preprint
Understanding how consciousness depends on large-scale brain interactions is key for both the neuroscience of consciousness and clinical translation. However, it requires moving beyond classical pairwise descriptions of functional connectivity, which cannot capture the collective dependencies emerging across multiple brain regions. Here, we use multivariate information theory measures to...
bioRxiv : the preprint server for biology
June 1, 2026
Panagiotis Fotiadis, Hyunwoo Jang, Rui Dai et al.
Brain waves are ubiquitous phenomena of human brain activity. As they propagate, they coordinate neural communication, shaping conscious perception. Understanding how brain waves unfold across space and time is thus critical for uncovering the neural mechanisms that support and suppress consciousness. Here, we analyzed data from the Human Connectome Project alongside multiple independent human...
bioRxiv
November 26, 2025
Rui Dai, Rodrigo Cofré, Christopher Timmermann et al.
preprint
The mechanism of psychedelic drug action is a dynamic area of neuroscience, with two major lines of investigation: (1) laboratory studies at the molecular and cellular level, and (2) human neuroimaging studies of functional brain networks. Despite considerable progress, there remains insufficient understanding of the link between molecular/cellular substrates of psychedelics and the whole-brain...
Elife
October 13, 2025
Guylaine Hoffner, Pablo Castro, Lynn Uhrig et al.
The resting primate brain is traversed by spontaneous functional connectivity patterns that show striking differences between conscious and unconscious states. Transcranial direct current stimulation (tDCS), a non-invasive neuromodulatory technique, can improve signs of consciousness in disorders of consciousness (DOCs); however, can it influence both conscious and unconscious dynamic...
Communications Biology
September 30, 2024
Pablo Castro, Andrea I. Luppi, Enzo Tagliazucchi et al.
21 citations
Resting-state functional magnetic resonance imaging evolves through a repertoire of functional connectivity patterns which might reflect ongoing cognition, as well as the contents of conscious awareness. We investigated whether the dynamic exploration of these states can provide robust and generalizable markers for the state of consciousness in human participants, across loss of consciousness...
Nature Communications
March 11, 2024
Andrea I. Luppi, Lynn Uhrig, Jordy Tasserie et al.
43 citations
A central challenge of neuroscience is to elucidate how brain function supports consciousness. Here, we combine the specificity of focal deep brain stimulation with fMRI coverage of the entire cortex, in awake and anaesthetised non-human primates. During propofol, sevoflurane, or ketamine anaesthesia, and subsequent restoration of responsiveness by electrical stimulation of the central...
Scientific Reports
April 17, 2023
Rubén Herzog, Pedro A. M. Mediano, Fernando E. Rosas et al.
51 citations
Psychedelic drugs, including lysergic acid diethylamide (LSD) and other agonists of the serotonin 2A receptor (5HT2A-R), induce drastic changes in subjective experience, and provide a unique opportunity to study the neurobiological basis of consciousness. One of the most notable neurophysiological signatures of psychedelics, increased entropy in spontaneous neural activity, is thought to be of...
Research Square
October 26, 2022
Rubén Herzog, Pedro A. M. Mediano, Fernando E. Rosas et al.
6 citations
Abstract Psychedelic drugs, including lysergic acid diethylamide (LSD) and other agonists of the serotonin 2A receptor (5HT2A-R), induce drastic changes in subjective experience, and provide a unique opportunity to study the neurobiological basis of consciousness. One of the most notable neurophysiological signatures of psychedelics, increased entropy in spontaneous neural activity, is thought...
Sci Rep
September 15, 2022
Rubén Herzog, Pedro A. M. Mediano, Fernando E. Rosas et al.
3 citations
s attention that there was a typo in the script used to calculate the differential entropy. Therefore, the reported entropy estimations are invalid and do not produce the expected increase in entropy when using
arXiv Preprint Archive
July 11, 2022
Matthieu Gilson, Enzo Tagliazucchi, Rodrigo Cofré
Consciousness is supported by complex patterns of brain activity which are indicative of irreversible non-equilibrium dynamics. While the framework of stochastic thermodynamics has facilitated the understanding of physical systems of this kind, its application to infer the level of consciousness from empirical data remains elusive. We faced this challenge by calculating entropy production in a...
Physical Review E
July 11, 2022
Matthieu Gilson, Enzo Tagliazucchi, Rodrigo Cofré
Consciousness is supported by complex patterns of brain activity which are indicative of irreversible nonequilibrium dynamics. While the framework of stochastic thermodynamics has facilitated the understanding of physical systems of this kind, its application to infer the level of consciousness from empirical data remains elusive. We faced this challenge by calculating entropy production in a...
Scientific Reports
October 20, 2020
Rubén Herzog, Pedro A. M. Mediano, Fernando E. Rosas et al.
60 citations
Retracted
Abstract Psychedelic drugs, including lysergic acid diethylamide and other agonists of the serotonin 2A receptor (5HT2A-R), induce drastic changes in subjective experience, and provide a unique opportunity to study the neurobiological basis of consciousness. One of the most notable neurophysiological signatures of psychedelics, increased entropy in spontaneous neural activity, is thought to be...
MDPI (MDPI AG)
September 10, 2020
Rodrigo Cofré
7 citations
The scope of human consciousness includes states departing from what most of us experience as ordinary wakefulness. These altered states of consciousness constitute a prime opportunity to study how global changes in brain activity relate to different varieties of subjective experience. We consider the problem of explaining how global signatures of altered consciousness arise from the interplay...
arXiv (Cornell University)
August 6, 2020
Rodrigo Cofré, Rubén Herzog, Pedro A. M. Mediano et al.
The scope of human consciousness includes states departing from what most of\nus experience as ordinary wakefulness. These altered states of consciousness\nconstitute a prime opportunity to study how global changes in brain activity\nrelate to different varieties of subjective experience. We consider the problem\nof explaining how global signatures of altered consciousness arise from...
arXiv Preprint Archive
August 6, 2020
Rodrigo Cofré, Rubén Herzog, Pedro A. M. Mediano et al.
The scope of human consciousness includes states departing from what most of us experience as ordinary wakefulness. These altered states of consciousness constitute a prime opportunity to study how global changes in brain activity relate to different varieties of subjective experience. We consider the problem of explaining how global signatures of altered consciousness arise from the interplay...