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Addiction: all studies

Page 455 of 860: studies 4,541 to 4,550 of 8,594, newest first. Back to the addiction overview

Research

Changes in adipokine concentrations in antidepressant-resistant bipolar depression after ketamine infusion and electroconvulsive therapy

The World Journal of Biological Psychiatry July 4, 2022 Monika Dmitrzak-Weglarz, M. Tyszkiewicz-Nwafor, Filip Rybakowski et al.

Abstract Objectives This study attempts to assess the concentration of two opposite-acting adipokines (anti-inflammatory adiponectin and pro-inflammatory resistin) in antidepressant-resistant patients undergoing ketamine infusion (KI) and electroconvulsive therapy (ECT). Methods The study group comprised 52 patients hospitalised due to episodes of depression in the course of bipolar disorders....

The Re–Enchantment with the Buddhist Perspective on Phenomenal Consciousness in the Contemporary Philosophy of Mind

Obnovljeni život July 4, 2022 Rajakishore Nath 1 citation

The present paper is concerned with a qualitative, analytical, and comparative method of exploring Buddhist perspectives on phenomenal consciousness. The phenomenal consciousness sciences have offered a mechanical explanation of the ‘how’ and ‘what’ of consciousness, but have failed to explain the ‘why’ of consciousness. The Buddhists have given a systematic explanation of conscious experience...

A simplified strategy to assess the cytotoxicity of new psychoactive substances in HepG2 cells using a high content screening assay - Exemplified for nine compounds.

Toxicology July 1, 2022 Tanja M Gampfer, Lea Wagmann, Benedikt Pulver et al.

New psychoactive substances (NPS) are an issue of global concern posing a serious threat to the healthcare systems. Consumption of some NPS has been associated with toxic effects on the liver amongst others. However, data concerning their (cyto-)toxicity are usually not available. For a straightforward assessment of their cytotoxic potential, a simplified strategy measuring six different...

Breathing affects self-other voice discrimination in a bodily state associated with somatic passivity.

Psychophysiology July 2022 Pavo Orepic, Hyeong-Dong Park, Giulio Rognini et al.

A growing number of studies have focused on identifying cognitive processes that are modulated by interoceptive signals, particularly in relation to the respiratory or cardiac cycle. Considering the fundamental role of interoception in bodily self-consciousness, we here investigated whether interoceptive signals also impact self-voice perception. We applied an interactive, robotic paradigm...

Ketamine-induced neurotoxicity is mediated through endoplasmic reticulum stress in vitro in STHdhQ7/Q7 cells.

Neurotoxicology July 2022 Nicolette Rigg, Fahed A Abu-Hijleh, Vidhi Patel et al.

Ketamine has traditionally been used as a dissociative anesthetic agent and more recently as a treatment for treatment-resistant depression. However, there is growing concern over the increased use of ketamine in recreational and therapeutic settings due to the potential neurotoxic effects. Recent studies have demonstrated that ketamine is cytotoxic in several cell types, such as fibroblasts,...

Effects of acute lysergic acid diethylamide on intermittent ethanol and sucrose drinking and intracranial self-stimulation in C57BL/6 mice.

Journal of Psychopharmacology July 2022 Lauri Elsilä, Juliana Harkki, Emma Enberg et al.

Psychedelics, like lysergic acid diethylamide (LSD), are again being studied as potential therapies for many neuropsychiatric disorders, including addictions. At the same time, the acute effects of psychedelics on rewarding behaviours have been scarcely studied. The current study aimed to clarify if LSD decreases binge-like ethanol drinking in mice, and whether the observed acute effects on...

Existential modes and their role in the modern perception of death

Известия Саратовского университета. Новая серия: Серия Философия. Психология. Педагогика July 1, 2022 Elena Mikhailovna Drokova

Introduction. The perception of death is inextricably linked with subjective experience, the feeling of the inevitability of this phenomenon. Theoretical analysis. Existential modes, such as fright, despair, fear, anxiety, actively studied in the corresponding philosophical trend, are the main aspects that determine this or that view on death in the context of personal experience of the...

Thalamic deep brain stimulation paradigm to reduce consciousness: Cortico-striatal dynamics implicated in mechanisms of consciousness.

PLoS Computational Biology July 1, 2022 Michelle J. Redinbaugh, Mohsen Afrasiabi, Jessica M. Phillips et al.

Anesthetic manipulations provide much-needed causal evidence for neural correlates of consciousness, but non-specific drug effects complicate their interpretation. Evidence suggests that thalamic deep brain stimulation (DBS) can either increase or decrease consciousness, depending on the stimulation target and parameters. The putative role of the central lateral thalamus (CL) in consciousness...

Psychedelic-inspired approaches for treating neurodegenerative disorders.

Journal of Neurochemistry July 1, 2022 Hannah N Saeger, David E. Olson 59 citations

Psychedelics are increasingly being recognized for their potential to treat a wide range of brain disorders including depression, post-traumatic stress disorder (PTSD), and substance use disorder. Their broad therapeutic potential might result from an ability to rescue cortical atrophy common to many neuropsychiatric and neurodegenerative diseases by impacting neurotrophic factor gene...

Psychedelic use in India, its pattern and personal significance – findings from an online survey

Indian Journal of Psychiatry July 1, 2022 Gokul Raj 3 citations

Sir, Psychedelic studies have reported positive results for depression and anxiety related to cancer and other life-threatening illnesses, treatment-resistant depression, and tobacco and alcohol dependence.[1] Although there are no active psychedelic research studies going on in India, there is growing interest about these substances as evident by numerous social media groups and pages with a...