Annales de Toxicologie Analytique
September 1, 2022
M. Augsburger, J. Déglon, Christèle Widmer et al.
Aim: Swiss drug policy aims to reduce recreational drug consumption and its negative consequences. The strategy is based on a four pillars concept: prevention, therapy, harm reduction and repression. Among harm reduction programs drug checking (DC) facilities have emerged, allowing drug users to check the presence of adulterants or other non-expected substances, and to gain information...
Psychiatric Annals
September 1, 2022
Mitch Earleywine, Zachary Herrmann
5 citations
Initial promise and dire need have inspired the multiple research programs of the second psychedelic renaissance. Serotonergic psychedelics (psilocybin, lysergic acid diethylamide, and ayahuasca) have decreased end-of-life anxiety in cancer patients, treatment-resistant depression, alcohol dependence, social anxiety in autistic adults, and nicotine dependence when applied with supportive...
Cureus
September 1, 2022
Joshua S Kurtz, Neal A Patel, Julian L Gendreau et al.
35 citations
Although early therapeutic research on psychedelics dates back to the 1940s, this field of investigation was met with many cultural and legal challenges in the 1970s. Over the past two decades, clinical trials using psychedelics have resumed. Therefore, the goal of this study was to (1) better characterize the recent uptrend in psychedelics in clinical trials and (2) identify areas where...
Alcoholism and Drug Addiction
August 31, 2022
Katarzyna Karaś, Katarzyna Groblińska, Krzysztof Szczygieł et al.
Research on the use of psychoactive substances in mental disorder treatment has become increasingly important over the last 50 years. Numerous publications suggest their effectiveness in the treatment of many diseases, including depression and anxiety disorders, PTSD, psychoactive substance dependence, ADHD and Tourette’s Syndrome. Particularly noteworthy is the use of psychedelics such as...
Nature Neuroscience
August 30, 2022
Polymnia Georgiou, Panos Zanos, Ta-Chung M. Mou et al.
We show that the sex of human experimenters affects mouse behaviors and responses following administration of the rapid-acting antidepressant ketamine and its bioactive metabolite (2R,6R)-hydroxynorketamine. Mice showed aversion to the scent of male experimenters, preference for the scent of female experimenters and increased stress susceptibility when handled by male experimenters. This...
arXiv Preprint Archive
August 29, 2022
Gerardo Iovane, Riccardo Emanuele Landi
preprint
This study proposes a model of computational consciousness for non-interacting agents. The phenomenon of interest was assumed as sequentially dependent on the cognitive tasks of sensation, perception, emotion, affection, attention, awareness, and consciousness. Starting from the Smart Sensing prodromal study, the cognitive layers associated with the processes of attention, awareness, and...
Biomedicine & Pharmacotherapy
August 29, 2022
Ines Erkizia-Santamaría, R. Alles-Pascual, Igor Horrillo et al.
108 citations
The psychedelic 5-HT2A receptor (5HT2AR) agonist psilocybin (or the active metabolite psilocin) has emerged as potential useful drug for various neuropsychiatric diseases, with a rapid onset of therapeutic activity. However, the mechanisms responsible for such effects remain incompletely characterized. We aimed to study in vitro pharmacological profile and in vivo acute mechanism of...
Behavioural Brain Research
August 26, 2022
Lakshmi Rajagopal, Mei Huang, Wenqi He et al.
Rapastinel, a positive N-methyl-D-aspartate receptor (NMDAR) modulator with rapid-acting antidepressant properties, rescues memory deficits in rodents. We have previously reported that a single intravenous dose of rapastinel, significantly, but only transiently, prevented and rescued deficits in the novel object recognition (NOR) test, a measure of episodic memory, produced by acute or...
Schizophrenia Research
August 25, 2022
Olga Santesteban-Echarri, Lu Liu, Madeline Miller et al.
Cannabis use is more prevalent among youth at clinical high-risk (CHR) for psychosis than healthy controls (HC). There is mixed evidence as to whether cannabis use is associated with increased severity of attenuated psychotic symptoms (APS) or whether current cannabis use is associated with the transition to psychosis. This study aims to assess cannabis use differences between CHR youth and HC...
Stress and Health
August 23, 2022
Abstract: This multi‐method study examined perspectives on mindfulness and coping strategies used by trauma‐exposed women experiencing homelessness (WEH), residing in a state‐funded residential drug treatment site in Southern California (United States). Questionnaires and in‐depth focus group interviews were utilised to examine traumatic experiences over the lifespan, probable‐posttraumatic...