Drug and Alcohol Dependence
February 1, 2023
Conor H. Murray, Margaret Haney, Richard W Foltin et al.
Despite the high prevalence of polysubstance use, outcomes and potential risks associated with common drug combinations are not well characterized. Many individuals who use cocaine also use cannabis, yet little is known about how interactions between the two drugs might contribute to continued co-use. The aim of this double-blind, placebo-controlled study was to determine the physiological and...
Cannabis and Cannabinoid Research
February 2023
Lia P Iglesias, Lucas Bedeschi, Daniele C Aguiar et al.
Δ9-THC (the main active compound from Cannabis sativa) and related cannabinoids have been used as drugs of abuse and as medications. They induce a complex set of emotional responses in humans and experimental animals, consisting of either anxiolysis or heightened anxiety. These discrepant effects pose a major challenge for data reproducibility and for developing new cannabinoid-based medicines....
Journal of Substance Use and Addiction Treatment
February 2023
Onawa LaBelle, Maurissa Hastings, Noel Vest et al.
Recovery Dharma (RD) is a Buddhist-based peer support program for the treatment of addiction that incorporates mindfulness and meditation into meetings, program literature, and the recovery process, creating the opportunity to study these variables in a peer-support program context. Mindfulness and meditation are beneficial for people in recovery, yet we know little about their relationship to...
Brain Science
February 1, 2023
Ahmed Hasbi, Bertha K. Madras, S. George
Background: There is a growing liberalization of cannabis-based preparations for medical and recreational use. In multiple instances, anxiety and depression are cited as either a primary or a secondary reason for the use of cannabinoids. Aim: The purpose of this review is to explore the association between depression or anxiety and the dysregulation of the endogenous endocannabinoid system...
Journal of Clinical Oncology
February 1, 2023
Lyudmyla Demyan, Oliver Standring, Taemoon Chung et al.
742 Background: Current biomarkers offer modest predictive capacity for drug sensitivity testing in pancreatic cancer. Patient-specific pharmacotyping offers the potential for a more direct, personalized prediction model. Recently, an implantable microdevice was developed to facilitate in situ multi-agent pharmacotyping and has since entered clinical trials in multiple cancer types, but had not...
Journal of Sleep Research
February 2023
Yaping Liu, Eemil Partinen, Ngan Yin Chan et al.
There has been increasing concern about the long-term impact of coronavirus disease 2019 (COVID-19) as evidenced by anecdotal case reports of acute-onset parkinsonism and the polysomnographic feature of increased rapid eye movement sleep electromyographic activity. This study aimed to determine the prevalence and correlates of dream-enactment behaviours, a hallmark of rapid eye movement sleep...
Addictive Behaviors
February 2023
Toni C Spinella, Jeremy Bartholomeusz, Sherry H Stewart et al.
Cannabis is associated with a range of therapeutic and non-therapeutic, positive and negative effects. While some benefits and harms may be specific to individual cannabinoid constituents (THC, CBD), individual expectancies may also play a role. Evaluate the extent to which individuals hold expectancies about the effects of CBD, THC, and THC & CBD combined, and whether this differs with prior...
Pharmaceuticals
February 1, 2023
Agnieszka Pałucha-Poniewiera, B. Bobula, Anna Rafało-Ulińska
(S)-Ketamine is the first rapid-acting antidepressant drug (RAAD) introduced for the treatment of depression. However, research is still being carried out on the search for further RAADs that will be not only effective but also safe to use. Recent data have indicated that the combined administration of (R)-ketamine and the mGlu2/3 receptor antagonist LY341495 (mixRL) induces rapid and sustained...
Consciousness and Cognition
February 1, 2023
Talis Bachmann, Jaan Aru
Progress in the science of consciousness depends on the experimental paradigms and varieties of contrastive analysis available to researchers. Here we highlight paradigms where the object is represented in consciousness as a set of its features but the interpretation of this set alternates in consciousness. We group experimental paradigms with this property under the label "conscious...
Theory & Psychology
February 1, 2023
Helen L Ma, Michael R W Dawson, Ruby S Prinsen et al.
4 citations
Cognitive psychology considers the environment as providing information, not affecting fundamental information processes. Thus, cognitive psychology's traditional paradigms study responses to precisely timed stimuli in controlled environments. However, new research demonstrates the environment does influence cognitive processes and offers cognitive psychology new methods. The authors examine...