Ketamine, an N-methyl-D-aspartate receptor antagonist, elicits swift antidepressant effects even in subjects with treatment-resistant depression. Nonetheless, owing to the serious adverse effects associated with ketamine, including psychotomimetic effects, the development of safer rapid-acting antidepressants is imperative. The elucidation of the mechanisms underlying the antidepressant effects...
Selective serotonin reuptake inhibitors (SSRIs), serotonin and noradrenaline reuptake inhibitors (SNRIs), and (es)ketamine are used to treat major depressive disorder (MDD). These different types of medication may involve common neural pathways related to glutamatergic and GABAergic neurotransmitter systems, both of which have been implicated in MDD pathology. We conducted a systematic review...
Ketamine, a non-competitive antagonist of the N-methyl-D-aspartate-glutamate receptor (R-NMDA), has a rapid (from 24 h post-dose) and prolonged (up to one week) antidepressant effect in treatment resistant depression and in rodent models of anxiety/depression. Arguments regarding its cellular and molecular mechanisms underlying its antidepressant activity mainly come from animal studies....
In France, suicidal behaviors remain a major public health issue. Depressed patients with suicidal ideation have more severe depressive symptoms, a more unfavorable disease course, and a greater number of suicide attempts than patients without suicidal ideation. Unfortunately, conventional antidepressants tend to be less effective in patients with suicidal tendencies than in those without....
RESUMEN.La ketamina es un medicamento conocido por sus bondades como inductor anestésico y para disminuir la posibilidad de complicaciones, por ejemplo, exacerbación del dolor neuropático e hiperalgesia asociada a opioides.En esta revisión nos enfocaremos en otras indicaciones en las que también ha demostrado ser útil y que, bajo observación e instrucción adecuadas en una infraestructura...
The effort to identify alternative treatments for anxiety has led to research into the potential of lysergic acid diethylamide (LSD) in reducing anxiety symptoms. Based on results of a placebo‐controlled pilot study showing that two high doses of LSD in patients with a life‐threatening illness resulted in reductions in anxiety for up to 2 months, investigators conducted a Phase 2 study to...
AbstractWith the publication of theHusserlianaseries and Heidegger’sGesamtausgabeboth nearing completion, a strikingly different picture of their work than was available to earlier generations is emerging. It has become quite clear that phenomenological philosophy is not a fixed “system” but an ongoing philosophical practice that has much to contribute to debates in contemporary philosophy...
It is common to distinguish between "holist" and "reductionist" views of brain function, where the former envisions the brain as functioning as an indivisible unit and the latter as a collection of distinct units that serve different functions. Opposing reductionism, a number of researchers have pointed out that cortical network architecture does not respect functional boundaries, and the...
The article addresses the following question: what is sense (smysl) as such, not to be confused with the sense of something. The sense as such sets the absolute limit for human consciousness, since we can be conscious only of that which makes sense, and, vice versa, what makes sense is part of our consciousness. Sense is devoid of semiotic nature, for sense as such cannot be conceptualized as...
This article will illustrate the development of the theme of language within Maurice Merleau-Ponty’s The Prose of the World (1973) in relation to Saussurean linguistics and Hendrik Pos’s phenomenology of language. Focusing on the concept of encroachment (empiètement) and on the inter-penetration between one’s own body and the other’s body, it will illustrate the strategic role played by an open...