Nature Medicine
June 2023
Margaret Haney, Monique Vallée, Sandy Fabre et al.
Cannabis use disorder (CUD) is widespread, and there is no pharmacotherapy to facilitate its treatment. AEF0117, the first of a new pharmacological class, is a signaling-specific inhibitor of the cannabinoid receptor 1 (CB1-SSi). AEF0117 selectively inhibits a subset of intracellular effects resulting from Δ9-tetrahydrocannabinol (THC) binding without modifying behavior per se. In mice and...
Drug and Alcohol Dependence
February 1, 2023
Conor H. Murray, Margaret Haney, Richard W Foltin et al.
Despite the high prevalence of polysubstance use, outcomes and potential risks associated with common drug combinations are not well characterized. Many individuals who use cocaine also use cannabis, yet little is known about how interactions between the two drugs might contribute to continued co-use. The aim of this double-blind, placebo-controlled study was to determine the physiological and...
American Journal of Psychiatry
June 24, 2019
Elias Dakwar, E. Nunes, C. Hart et al.
179 citations
OBJECTIVE Research has suggested that subanesthetic doses of ketamine may work to improve cocaine-related vulnerabilities and facilitate efforts at behavioral modification. The purpose of this trial was to test whether a single ketamine infusion improved treatment outcomes in cocaine-dependent adults engaged in mindfulness-based relapse prevention. METHODS Fifty-five cocaine-dependent...
Neuropharmacology
November 1, 2018
Elias Dakwar, Edward V. Nunes, Carl L. Hart et al.
83 citations
Efforts to translate sub-anesthetic ketamine infusions into widespread clinical use have centered around developing medications with comparable neurobiological activity, but with attenuated psychoactive effects so as to minimize the risk of behavioral toxicity and abuse liability. Converging lines of research, however, suggest that some of the psychoactive effects of sub-anesthetic ketamine may...
Drug and Alcohol Dependence
September 1, 2017
Diana R Keith, Erik W. Gunderson, Margaret Haney et al.
Individuals who work nonstandard schedules, such as rotating or night shifts, are more susceptible to workplace injuries, performance decrements, and reduced productivity. This population is also almost twice as likely to use illicit drugs as individuals working a standard day shift. The purpose of this study was to examine the effects of smoked marijuana on performance, mood, and sleep during...
Biological Psychiatry
September 12, 2013
Elias Dakwar, Frances R. Levin, Richard W Foltin et al.
Background: Cocaine dependence involves problematic neuroadaptations that might be responsive to modulation of glutamatergic circuits. This investigation examined the effects of subanesthetic ketamine infusions on motivation for quitting cocaine and on cue-induced craving in cocaine-dependent participants, 24 hours postinfusion. Methods: Eight volunteers with active DSM-IV cocaine dependence...
Psychopharmacology
June 30, 2011
M. Kirkpatrick, Erik W. Gunderson, Audrey Y. Perez et al.
119 citations
Despite their chemical similarities, methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) produce differing neurochemical and behavioral responses in animals. In humans, individual studies of methamphetamine and MDMA indicate that the drugs engender overlapping and divergent effects; there are only limited data comparing the two drugs in the same individuals. This study examined the...
Pharmacology, Biochemistry, and Behavior
September 2010
Carl L. Hart, Aaron B Ilan, Alan Gevins et al.
Previously, we reported that acute marijuana intoxication minimally affected complex cognitive performance of daily marijuana smokers. It is possible that the cognitive tests used were insensitive to marijuana-related cognitive effects. In the current study, electroencephalographic (EEG) signals were recorded as daily marijuana users performed additional tests of immediate working memory and...
Psychopharmacology
February 2003
Margaret Haney, Adam Bisaga, Richard W Foltin
Studies in non-human animals suggest that opioid antagonists block the reinforcing effects of cannabinoids. The present studies in humans investigated how naltrexone modulates (1) the subjective and physiological effects of oral THC in comparison to methadone, (2) the reinforcing effects of oral THC, and (3) plasma levels of oral THC. In study 1, marijuana smokers (n=9) received naltrexone (0,...
Psychopharmacology
January 2003
Margaret Haney, Carl L. Hart, Amie S Ward et al.
Symptoms of marijuana withdrawal include increased irritability, depression and anxiety, and decreased sleep quality. Nefazodone, which is an antidepressant with sedative properties, may attenuate symptoms of marijuana withdrawal. The present within-subject, placebo-controlled study investigated the effects of nefazodone during marijuana withdrawal. Marijuana smokers [ n=7; averaging 6.0...
Drug and Alcohol Dependence
August 1, 2002
Carl L. Hart, Margaret Haney, Amie S Ward et al.
Studies have shown that the Delta(9)-tetrahydrocannabinol (Delta(9)-THC) concentration in marijuana cigarettes is an important factor for the maintenance of marijuana self-administration. Yet, the impact of oral Delta(9)-THC treatment on marijuana self-administration is unknown. Because other agonist therapies have been demonstrated to be effective for the treatment of substance use disorders,...
Neuropsychopharmacology
November 2001
Carl L. Hart, W Van Gorp, Margaret Haney et al.
Although the ability to perform complex cognitive operations is assumed to be impaired following acute marijuana smoking, complex cognitive performance after acute marijuana use has not been adequately assessed under experimental conditions. In the present study, we used a within-participant double-blind design to evaluate the effects acute marijuana smoking on complex cognitive performance in...
Psychopharmacology
February 1, 1999
Margaret Haney, Amie S Ward, S D Comer et al.
Symptoms of dependence and withdrawal after the frequent administration of high doses (210 mg/day) of oral delta9-tetrahydrocannabinol (THC) have been reported, yet little is known about dependence on lower oral THC doses, more relevant to levels attained by smoking marijuana. In a 20-day residential study, male (n = 6) and female (n = 6) marijuana smokers worked on five psychomotor tasks...
Pharmacology, Biochemistry, and Behavior
November 1994
T H Kelly, Richard W Foltin, M T Mayr et al.
The effects of time of day and social context on daily patterns of marijuana self-administration were examined in two groups of three adult male marijuana smokers during a 12-day residential study. Days were divided into 6.5-h work and social-access periods. Order of occurrence (i.e., work before social access or social access before work) was counterbalanced between groups and reversed for...