(S)-Ketamine is the first rapid-acting antidepressant drug (RAAD) introduced for the treatment of depression. However, research is still being carried out on the search for further RAADs that will be not only effective but also safe to use. Recent data have indicated that the combined administration of (R)-ketamine and the mGlu2/3 receptor antagonist LY341495 (mixRL) induces rapid and sustained...
Progress in the science of consciousness depends on the experimental paradigms and varieties of contrastive analysis available to researchers. Here we highlight paradigms where the object is represented in consciousness as a set of its features but the interpretation of this set alternates in consciousness. We group experimental paradigms with this property under the label "conscious...
Cognitive psychology considers the environment as providing information, not affecting fundamental information processes. Thus, cognitive psychology's traditional paradigms study responses to precisely timed stimuli in controlled environments. However, new research demonstrates the environment does influence cognitive processes and offers cognitive psychology new methods. The authors examine...
Although results are still preliminary, ketamine and classical hallucinogens have shown promise in recent years as novel, fast-acting antidepressants, especially for the treatment of unipolar treatment-resistant depression (TRD). Depression also seems to be related to abnormal levels of peripheral inflammatory and neurotrophic biomarkers, which may one day help to diagnose of this disorder. In...
Sleep paralysis is characterized by the incapacity to perform voluntary movements during sleep/wake transitions, and could bring great discomfort. During sleep paralysis, out-of-body experiences can occur. Out-of-body experiences refers to the sensation of being outside of the physical body and perceiving the world from this outside perspective; however, they are pleasant in comparison with...
Plants of Tabernaemontana species have several pharmacological activities including antimicrobial effects. Amoebiasis continues to be a public health problem, with increasing evidence of resistance to metronidazole. In this study, we assessed the effect of the alkaloid fraction of T. arborea root bark and the alkaloids ibogaine and voacangine on the viability and infectivity of Entamoeba...
Classic psychedelic-induced ego dissolution involves a shift in the sense of self and a blurring of the boundary between the self and the world. A similar phenomenon is identified in psychopathology and is associated with the balance of anticorrelated activity between the default mode network, which directs attention inward, and the salience network, which recruits the dorsal attention network...
A topic of growing interest in computational neuroscience is the discovery of fundamental principles underlying global dynamics and the self-organization of the brain. In particular, the notion that the brain operates near criticality has gained considerable support, and recent work has shown that the dynamics of different brain states may be modeled by pairwise maximum entropy Ising models at...
In this paper we present an exploratory study on the understanding of reality among scientists. The nature of reality has been a conundrum for generations of theologians, philosophers, and scientists as well as the lay public. It also appears as a scientific problem in various disciplines, from physics to psychiatry and neuroscience. For the purpose of our study, we employed Chamber REST...
In [1] it is claimed that, based on radiation emission measurements described in [2], a certain "variant" of the Orch OR theory has been refuted. I agree with this claim. However, the significance of this result for Orch OR per se is unclear. After all, the refuted "variant" was never advocated by anyone, and it contradicts the views of Hameroff and Penrose (hereafter: HP) who invented Orch OR...