Journal of Substance Use and Addiction Treatment

Treatment and management approaches for ketamine misuse: A systematic review of medical interventions

Journal of Substance Use and Addiction Treatment July 1, 2026 Alessio Mosca, Stefania Chiappini, Andrea Miuli et al.

INTRODUCTION: Ketamine, initially developed as an anesthetic and now increasingly prescribed for treatment-resistant depression, is also widely misused in recreational contexts. Chronic ketamine use, often leading to dependence, has been associated with severe physical complications, including ulcerative cystitis and gastrointestinal dysfunction, as well as cognitive, affective, and psychotic...

DOI: 10.1016/j.josat.2026.210061 Ketamine Psychological intervention Medline Systematic review +2

Role of ketamine in the treatment of substance use disorders: A systematic review.

Journal of Substance Use and Addiction Treatment August 1, 2025 Reinhard Janssen-Aguilar, Shakila Meshkat, Ilya Demchenko et al. 12 citations

Substance Use Disorders (SUDs) involve diminished control, risky use, impaired social interactions, and physical dependence. Despite their global prevalence and burden, treatment options remain limited. Ketamine (KET), an NMDA receptor antagonist, may aid SUD treatment by modulating glutamatergic neurotransmission. This systematic review evaluates KET's role in SUD treatment. This review...

DOI: 10.1016/j.josat.2025.209705 Full text Sud Systematic review Addiction treatment Ketamine therapy +3

Preparations for rave music parties and consequences for attendees who consume psychedelic drugs.

Journal of Substance Use and Addiction Treatment May 1, 2025 Yula Milshteyn, Moshe Bensimon 1 citation

A few studies have shown that rave music parties (RMP) enabled long-term positive transformative experiences. However, phenomenological inquiry on the subjective meaning of RMP attendees' experience before and after such parties is scant. The present study explored the preparations for participation in RMP and the parties' consequences for attendees who consume psychedelic drugs. The study used...

DOI: 10.1016/j.josat.2025.209637 Full text Interpretative phenomenological analysis Liminality Psychedelic drugs Rave music +1

Patterns of mean age at drug use initiation by race and ethnicity, 2004-2019.

Journal of Substance Use and Addiction Treatment June 1, 2024 Karl C Alcover, Abram J Lyons, Solmaz Amiri 7 citations

Adolescent drug use can result in clinically significant psychiatric outcomes later in life mitigated by targeted prevention strategies. While mean age of drug initiation has increased over time, there is little research of mean age of drug initiation among adolescents by race/ethnicity. The study used the National Survey on Drug Use and Health data (2004-2019). Sample included individuals aged...

DOI: 10.1016/j.josat.2024.209350 Full text Adolescent health Drug initiation Race and ethnicity Drug prevention +3

Efficacy of mindfulness-based relapse prevention in a sample of veterans in a substance use disorder aftercare program: A randomized controlled trial.

Journal of Substance Use and Addiction Treatment September 1, 2023 Therese K Killeen, Nathaniel L Baker, Lori L. Davis et al. 3 citations

Complementary integrative medicine, such as mindfulness-based interventions, (MBI) have demonstrated efficacy in the treatment of depression, anxiety, substance use disorders (SUDs), and pain. Mindfulness-based relapse prevention (MBRP) is an aftercare intervention targeting SUD relapse that integrates cognitive-behavioral relapse prevention and mindfulness meditation practices, raising...

DOI: 10.1016/j.josat.2023.209116 Full text Mindfulness Substance use disorder Veterans

Identifying early intervention opportunities for illicit stimulant use: A cross-sectional study of factors associated with illicit stimulant use among young people accessing integrated youth services in British Columbia, Canada.

Journal of Substance Use and Addiction Treatment August 1, 2023 Sara Kreim, Kirsten Marchand, Emilie Mallia et al. 2 citations

Illicit stimulant (cocaine and/or amphetamine) use among young people aged 12-24 is a public health priority given that substance use initiation tends to peak in this developmental period and significant associated immediate and long-term harms are associated with its use. Young people using stimulants must be engaged in services as early as possible to reduce these harms. To inform early...

DOI: 10.1016/j.josat.2023.209076 Full text Adolescents Amphetamine Cocaine Early interventions +3

Investigating the associations of acute psychedelic experiences and changes in racial trauma symptoms, psychological flexibility, and substance use among People with Racial and Ethnic Minoritized Identities in the United States and Canada.

Journal of Substance Use and Addiction Treatment June 1, 2023 Angela M Haeny, Joel A Lopez, Pamela A Colón Grigas et al. 10 citations

Evidence suggests that psychedelics may serve as a therapeutic approach to reduce substance use; however, people with racial and ethnic minoritized (REM) identities are often excluded from this research. We investigated whether psychedelic use affects other substance use among REM people and whether perceived changes in psychological flexibility and racial trauma mediates this association. REM...

DOI: 10.1016/j.josat.2023.209035 Full text Alcohol Drug People of color Psychedelic +1

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