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Manvir Singh 35 citations
Shamans, including medicine-men, mediums, and the prophets of religious movements, recur across human societies. Shamanism also existed among nearly all documented hunter-gatherers, likely characterized the religious lives of many ancestral humans, and is often proposed by anthropologists to be the “first profession”, representing the first institutionalized division of labor beyond age and...
Bernard J. Crespi, Nancy Yang, Sam M Doesburg preprint
The human brain apparently harbors no network or region uniquely dedicated to spiritual or religious thought, or clearly evolved specifically in these contexts. God is thus nowhere in the brain. Could God, instead, be virtually everywhere in the brain? We propose and evaluate the hypothesis that religious and spiritual cognition are derived predominantly from the effects of (virtually...
Michael Timothy Bennett, Sean Welsh
Please note this is a draft on which we are seeking feedback. Substantial changes and a third author are likely be added to the next version. The hard problem of consciousness asks why there is something it is like to be a conscious organism. We address this from 1st principles, by constructing a formalism that unifies lower and higher order theories of consciousness. We assume...
Viviana D. Evans, Alejandro Arenas, Kenneth Shinozuka et al. preprint
Background: Ketamine, an arylcyclohexylamine dissociative anesthetic agent, has evolved into a versatile therapeutic. It has a rapid onset, well-understood cardiovascular effects, and a favorable safety profile in clinical use. Its enantiomeric compound, esketamine, was approved by the FDA in 2019 for both treatment-resistant depression as well as major depressive disorder (MDD) with suicidal...
Kenneth Shinozuka, Burton J. Tabaac, Alejandro Arenas et al. preprint
Background: After becoming notorious for its use as a party drug in the 1980s, 3,4-methylenedioxy-methampetamine (MDMA), also known by its street names “molly” and “ecstasy,” has emerged as a powerful treatment for post-traumatic stress disorder (PTSD). Areas of uncertainty: There is extensive data about the risk profile of MDMA. However, the literature is significantly biased. Animal models...
Research Square Ulrich Gergs, Hannes Jacob, Pauline Braekow et al. 1 citation preprint
Abstract Introduction: Lysergic acid diethylamide (LSD) is an artificial hallucinogenic drug. Thus, we hypothesized that LSD might act 5-HT4 serotonin receptors and/or H2 histamine receptors. Methods: We studied isolated electrically stimulated left atrial preparations, spontaneously beating right atrial preparations, and spontaneously beating Langendorff-perfused hearts from transgenic mice...
bioRxiv (Cold Spring Harbor Laboratory) Shawn. M. Aarde, Pai-Kai Huang, Michael A. Taffe 1 citation preprint
Abstract Rationale MDMA alters body temperature in rats with a direction that depends on the ambient temperature (T A ). The thermoregulatory effects of MDMA and T A may affect intravenous self-administration (IVSA) of MDMA but limited prior reports conflict. Objective To determine how body temperature responses under high and low T A influence MDMA IVSA. Methods Male Sprague-Dawley rats were...
bioRxiv (Cold Spring Harbor Laboratory) M. A. Taffe preprint
Abstract Hyperthermic responses are commonly reported in cases of human medical emergency following recreational use of 3,4-methylenedioxymethamphetamine (MDMA, “Ecstasy”), but a precise determination of contributing environmental factors has been elusive given the relative scarcity of threatening and fatal reactions in humans. This study was conducted to determine if elevated physical activity...
Mika Turkia preprint
This article describes a case of a 'spiritual attack' in the context of Amazonian ayahuasca ceremonies. These attacks are often assumed to be imaginary, and there is relatively little information available about them. Specifically, there appears to be no documentation about possible mechanisms of action for these attacks. Subjectively, they typically appear as context-dependent visions or...
University of North Texas Digital Library (University of North Texas) Bianchi
Abstract: Although ketamine can induce a state similar to a near-death experience (NDE), there is a striking difference between experiences induced by ketamine used in a recreational context and in an operating room. Ketamine is a noncompetitive antagonist of the N-methyl-D-aspartate receptor, as is ibogaine, the main alkaloid of a shrub used in Central Africa to induce NDEs in a religious...