European Journal of Pharmacology
November 1, 2022
Júlia Grigorini Mori Ayub, C. Tosta, Breno Lopes Macedo et al.
Since a significant body of studies supports the involvement of glutamatergic neurotransmission in the neurobiology of obsessive-compulsive disorder (OCD). Ketamine, a glutamate N-methyl-D-aspartate (NMDA) receptor antagonist with rapid and sustained antidepressant effect, raises as a potential new anti-OCD drug. Evidence from pre-clinical studies indicates that female mice are more sensitive...
Perspectives on Psychological Science
November 1, 2022
Moti Salti, Dafna Bergerbest
In the study of consciousness, qualia, the individual subjective experience, is neglected. It remains impenetrable because the objective perspective used for scientific investigations misses its subjective nature. In 1974, Thomas Nagel suggested that studying qualia requires an "objective phenomenology method" whose goal would be to describe the subjective character of experiences in an...
Neuroscience & Biobehavioral Reviews
November 1, 2022
Megan A. K. Peters
Science and philosophy have long struggled with how to even begin studying the neural or computational basis of qualitative experience. Here I review psychological, neuroscience, and philosophical literature to reveal how perceptual metacognition possesses five unique properties that provide a powerful opportunity for studying the neural and computational correlates of subjective experience:...
Preprints.org
November 1, 2022
Kristina Puls, Gerhard Wolber
preprint
The natural product Salvinorin A (SalA) was the first nitrogen-lacking agonist discovered for the opioid receptors and exhibits high selectivity for the kappa opioid receptor (KOR) turning SalA into a promising analgesic to overcome the current opioid crisis. Since SalA’s suffers from poor pharmacokinetic properties, particularly the absence of gastrointestinal bioavailability, fast metabolic...
European Journal of Neuroscience
November 1, 2022
Lau M Andersen, Mikkel C Vinding, Kristian Sandberg et al.
In the search for the neural correlates of consciousness, it is often assumed that there is a stable set within the relevant sensory modality. Within the visual modality, the debate has centred upon whether frontal or occipital activations are the best predictors of perceptual awareness. Although not accepted by all as definitive evidence, no-report and decoding studies have indicated that...
The Lancet Psychiatry
November 1, 2022
Sanne Y Smith-Apeldoorn, Jolien K E Veraart, Jan Spijker et al.
163 citations
Ketamine has rapid yet often transient antidepressant effects in patients with treatment-resistant depression. Different strategies have been proposed to prolong these effects. Maintenance ketamine treatment appears promising, but little is known about its efficacy, safety, and tolerability in depression. We searched Pubmed, Embase, and the Cochrane Library and identified three randomised...
Naunyn-Schmiedeberg's Archives of Pharmacology
November 1, 2022
Joachim Neumann, Karyna Azatsian, Christian Höhm et al.
7 citations
Abstract The use of recreational drugs like ephedrine, norephedrine, 3,4-methylenedioxymethamphetamine (MDMA), and mescaline can lead to intoxication and, at worst, to death. One reason for a fatal course of intoxication with these drugs might lie in cardiac arrhythmias. To the best of our knowledge, their inotropic effects have not yet been studied in isolated human cardiac preparations....
Cureus
November 1, 2022
Ricardo Irizarry, Amelia Winczura, Omar Dimassi et al.
26 citations
Psilocybin is an emerging potential therapy for the treatment of psychiatric illnesses. Microdosing has been shown to result in an overall improvement in patients with anxiety, depression, obsessive-compulsive disorder, post-traumatic stress disorder, and substance abuse. This meta-analysis explores and compiles prior research to make further inferences regarding psilocybin and its use for the...
October 31, 2022
Sonia Romero Martinez, Andres Villamil Dueñas, Xavier Ordoñes
4 citations
This randomized comparison study measured the impact of brief daily use of two types of kundalini yoga meditation from the Yogi Bhajan lineage on self-esteem, regulatory emotional self-efficacy, and positive and negative affect in a non-clinical sample of 46 Spanish-speaking adults residing in Spain. Results of the two meditation types—Kirtan Kriya and Internal Conflict Resolution—are compared....
Journal of Psychopharmacology
October 31, 2022
Grant Jones
28 citations
Background: Psychedelics are receiving renewed attention within Western medicine as they represent potential treatments for many difficult-to-treat mental health disorders. However, psychedelic science is limited in its focus and inclusion of racial and ethnic minorities. Hence, this study examines whether race and ethnicity moderate the associations that naturalistic...