Planta Medica
March 1, 2026
K Knížková, D Lovás, R Batelková et al.
Tabernanthe iboga is a plant containing a broad spectrum of alkaloids, the most significant of which is ibogaine. This alkaloid has been proven effective in the treatment of addiction to various substances, as it alleviates withdrawal symptoms and reduces cravings. Due to these properties, ibogaine clinics have emerged worldwide, incorporating ibogaine into treatment programs. [ 1 ] [ 2 ]...
Planta Medica
February 1, 2023
Julio César Carrero, Violeta Curay-Herrera, Lysette Chacón-niño et al.
6 citations
Plants of Tabernaemontana species have several pharmacological activities including antimicrobial effects. Amoebiasis continues to be a public health problem, with increasing evidence of resistance to metronidazole. In this study, we assessed the effect of the alkaloid fraction of T. arborea root bark and the alkaloids ibogaine and voacangine on the viability and infectivity of Entamoeba...
Planta Medica
December 1, 2022
Prokopios Magiatis, Evangelos Dadiotis, Romanos Konstantinos Antonopoulos et al.
1 citation
The genus Psilocybe of Basidiomycota includes more than two hundred species of mushroom-forming fungi, which are widely known for the production of the secondary metabolite psilocybin, a prodrug of its in vivo dephosphorylated active metabolite psilocin [1]. Psilocybin is being currently used in numerous clinical trials including the treatment of Major Depressive Disorder (MDD) [2], existential...
Planta Medica
November 1, 2022
Matteo Politi, Giorgia Tresca, Luigi Menghini et al.
19 citations
The herbal preparation ayahuasca has been an important part of ritual and healing practices, deployed to access invisible worlds in several indigenous groups in the Amazon basin and among mestizo populations of South America. The preparation is usually known to be composed of two main plants, Banisteriopsis caapi and Psychotria viridis, which produce both hallucinogenic and potent purging and...
Planta Medica
March 2, 2018
Ulrike Steiner, Eckhard Leistner
28 citations
Abstract Naturally occurring and semisynthetic ergot alkaloids play a role in health care or as recreational drugs in Western and indigenous Mexican societies. Evidence is summarized that ergot alkaloids present in Central American Convolvulaceae like Turbina corymbosa, Ipomoea violacea, and Ipomoea asarifolia are colonized by different species of a newly described clavicipitaceous fungal genus...
Planta Medica
August 1, 2011
JK Zjawiony, PR Polepally, B.l. Roth et al.
10 citations
Psychoactive natural products play an important role in the discovery and development of new drugs for the treatment of central nervous system (CNS) disorders. Our studies are focusing on identification of plant metabolites responsible for CNS activity and designing new ligands with high affinity to CNS receptors. Salvinorin A, the most potent naturally occurring hallucinogen isolated from the...
Planta Medica
March 1, 2011
Lj Standish, Dean B. Reardon, Simon Phipps et al.
Ayahuasca is an ancient psychoactive ethnobotanical medicine tea used by indigenous S. American tribes as a religious sacrament. It is made from the vine of B. caapi and the leaves of P. viridis and represents an ancient yet 'novel' short and long-term serotonin agonist. Here we present preclinical pharmacognosy data as an early step towards phase I and II clinical trials of ayahuasca in...
Planta Medica
September 1, 2010
Stephen M Phipps, Veronika Butterweck
The compulsive gnawing (CG) test has been used for numerous years as an assay to determine the dopaminergic activity of various compounds. We developed a new method of quantification via a digitization step which allowed a more precise measurement of the gnawing activity. It was the aim of the present study to explore possible dopaminergic effects of salvinorin A (SA), the major active compound...
Planta Medica
July 1, 2008
Mario Marchi, Massimo Grilli, Elisa Neri et al.
Salvinorin-A is a component of Salvia divinorum , displaying psychoactive and hallucinogenic properties in humans. Recent literature suggests that this compound can act as a potent and selective opioid receptor agonist, having high affinity towards the K–opioid receptor subtype. The aim of our study was to investigate whether and to what extent this compound can alter the release of...
Planta Medica
August 1, 2007
Oliver Grundmann, Stephen M Phipps, Immo Zadezensky et al.
81 citations
Salvia divinorum L. (Lamiaceae) has been used for centuries by the Mazatecan culture and has gained popularity as a recreational drug in recent years. Its potent hallucinogenic effects seen in case reports has triggered research and led to the discovery of the first highly selective non-nitrogenous kappa opioid receptor agonist salvinorin A. This review critically evaluates the reported...
Planta Medica
April 1, 2006
Niels Jensen, Jochen Gartz, Hartmut Laatsch
56 citations
The hallucinogenic mushroom Inocybe aeruginascens contains several typical Psilocybe alkaloids including psilocybin. We have now elucidated the structure of a further indole derivative named aeruginascin as the quaternary ammonium compound N, N, N-trimethyl-4-phosphoryloxytryptamine. Aeruginascin is closely related to the frog skin toxin bufotenidine (5-HTQ), a potent 5-HT3 receptor agonist,...
Planta Medica
February 1, 2006
W. Kubelka
1 citation
On January 11th, 2006, Dr. Dr. h. c. mult. Albert Hofmann, Honorary Member of the Society for Medicinal Plant Research and of the American Society of Pharmacognosy, had the good fortune to celebrate his 100th birthday, and what else, if not this event, would be a perfect reason for cordial congratulations![ * ] [ * ] ”It is said and written again and again, that LSD was a pure chance discovery....
Planta Medica
June 1, 1989
Jochen Gartz
13 citations
Mycelial cultures of PSILOCYBE CUBENSIS, with the ability to form psilocybin and psilocin DE-NOVO, also hydroxylated and methylated fed tryptamine to give psilocin in up to 3.3% dry mass of the obtained fruit bodies. By using HPLC and TLC, it was found that these mushrooms contain only a small amount of psilocybin (0.01-0.2% dry mass). The values of psilocin are the highest described in any...
Planta Medica
December 1, 1987
J. Gartz
20 citations
INOCYBE AERUGINASCENS contains psilocybin, baeocystin, and aeruginascin with a still unknown structure in the caps and the stipes. The content of psilocybin and baeocystin has been investigated. The psilocybin and baeocystin content of mushrooms from the same location and with similar mass varied. No correlation has been found between the mass of the mushrooms and the content of psilocybin and...
Planta Medica
June 1, 1987
J. Gartz
10 citations
Using HPLC and TLC, psilocybin and baeocystin but not psilocin were found in extracts of dried fruit bodies of PLUTEUS SALICINUS. Caps contain more psilocybin than stems. The amount of psilocybin varies and was as high as 1.57% in the caps. Urea was also detected. This substance is virtually exclusively localized in the caps. Baeocystin and tryptophan were also found only in the caps. There was...
Planta Medica
April 1, 1986
Marta Semerdžieva, M. Wurst, T. Koza et al.
20 citations
Psilocybin was quantitatively determined in methanolic extracts of dried fruiting-bodies of the basidiomycete Inocybe aeruginas-cens and its content was compared with that in Psilocybe bohemica and P. semilanceata. By menas of HPLC it was found that the content of psilocybin in Inocybe aeruginascens is lower than in Psilocybe species. Similarly to Psilocybe, the content of psilocybin in Inocybe...
Planta Medica
October 1, 1985
T. Stijve, Th.w. Kuyper
43 citations
Using high performance liquid and thin-layer chromatographic methods more than 100 species of fungi from Europe belonging to 18 genera were analysed for the hallucinogenic compound psilocybin and for some related tryptamine derivatives. Psilocybin, psilocin and/or baeocystin were found in 3 PSILOCYBE 1 PANAEOLUS, 5 INOCYBES and one PLUTEUS. PSILOCYBE SEMILANCEATA and PANAEOLUS SUBBALTEATUS...
Planta Medica
August 1, 1984
Anders Christiansen, Knut Rasmussen, Klaus Høiland
13 citations
A screening of Norwegian mushrooms for the presence of hallucinogenic indole alkaloids was carried out using HPLC with ultraviolet, fluorescence and electrochemical detection. The analysis revealed psilocybin and psilocin in two mushroom species: PLUTEUS SALICINUS and CONOCYBE CYANOPUS. The content of psilocybin and psilocin in dried material of PLUTEUS SALICINUS was determined to be 0.35% and...
Planta Medica
June 1, 1984
J. Jokiranta, S. Mustola, E. Ohenoja et al.
7 citations
The use of a hallucinogenic mushroom, PSILOCYBE SEMILANCEATA, has been occasionally reported in Finland, where the species is widely distributed. We have determined, by HPLC, the content of psilocybin and psilocin in P. SEMILANCEATA samples collected from different parts of Finland; the psilocybin content was found to be high (0.62-2.37%, mean 1.42% of dry weight), some samples also contained...
Planta Medica
July 1, 1981
Anders Christiansen, Knut Rasmussen, Klaus Høiland
20 citations
Psilocybe semilanceata contains hallucinogenic indole alkaloids and has been used as a narcotic drug in Norway. The content of psilocybin, the major constituent in Norwegian P. semilanceata, has been investigated as well as its habitats and its distribution throughout the country. The mushroom is growing on grassy sites in most parts of Norway from the middle of August to the middle of October....
Planta Medica
March 1, 1972
S. P. Ghosal
8 citations
Over two dozen Indian medicinal plants belonging to the families Leguminosae, Gramineae, and Malpighiaceae have been screened for potential psychodelic substances. The evaluation of only the indole bearing plants is reported here. Localization of about forty indole alkaloids, representing four broad structural types, viz., indole–3–alkylamines, carboxylated tryptamines, β–carbolines, and...
Planta Medica
February 1, 1971
S. Ghosal, Saumitra Sen Singh, S. Bhattacharya
39 citations
Four indole–3–alkylamines, viz., N,N–dimethyltryptamine, its N b –oxide, bufo–tenine, and 5–methoxy–N,N–dimethyltryptamine along with two uncharacterized 5–oxy–indole–3–alkylamines and a β–carboline were isolated from the various parts, except the trichomes of pods, of Mucuna pruriens DC. The trichomes of pods afforded only serotonin. Besides these, choline was found in all parts of the plant....