Life Science
May 1, 2023
Miroslav Adzic, Iva Lukic, Milos Mitic et al.
Major depressive disorder (MDD) afflicts approximately 5 % of the world population, and about 30-50 % of patients who receive classical antidepressant medications do not achieve complete remission (treatment resistant depressive patients). Emerging evidence suggests that targeting opioid receptors mu (MOP), kappa (KOP), delta (DOP), and the nociceptin/orphanin FQ receptor (NOP) may yield...
European Neuropsychopharmacology
May 2023
Giacomo d'Andrea, Mauro Pettorruso, Giorgio Di Lorenzo et al.
Ketamine and esketamine, the S-enantiomer of the racemic mixture, have recently generated considerable interest as potential therapeutic agents for Treatment-Resistant Depression (TRD), a complex disorder that includes various psychopathological dimensions and distinct clinical profiles (e.g., comorbid personality disorder, bipolar spectrum, dysthymic disorder). This perspective article...
BJPsych Open
May 1, 2023
Bess M. Kew, Richard Porter, Katie M. Douglas et al.
65 citations
BACKGROUND: Ketamine is an effective short-term treatment for a range of psychiatric disorders. A key question is whether the addition of psychotherapy to ketamine treatment improves outcomes or delays relapse. AIM: To identify all studies combining psychotherapy with ketamine for the treatment of psychiatric disorders to summarise their effects and make recommendations for future research....
Trends in Cognitive Sciences
May 1, 2023
Biyu J. He
Theories of consciousness are often based on the assumption that a single, unified neurobiological account will explain different types of conscious awareness. However, recent findings show that, even within a single modality such as conscious visual perception, the anatomical location, timing, and information flow of neural activity related to conscious awareness vary depending on both...
Psychological Medicine
May 1, 2023
David Van den Berg, Eva Tolmeijer, Alyssa Jongeneel et al.
Post-traumatic mechanisms are theorised to contribute to voice-hearing in people with psychosis and a history of trauma. Phenomenological links between trauma and voices support this hypothesis, as they suggest post-traumatic processes contribute to the content of, and relationships with, voices. However, research has included small samples and lacked theory-based comprehensive assessments. In...
Primates; journal of primatology
May 1, 2023
Adriano R. Lameira, Marcus Perlman
7 citations
Among animals, humans stand out in their consummate propensity to self-induce altered states of mind. Archaeology, history and ethnography show these activities have taken place since the beginnings of civilization, yet their role in the emergence and evolution of the human mind itself remains debatable. The means through which modern humans actively alter their experience of self and reality...
Sleep
May 1, 2023
Afik Faerman, Lauren Anker, Kirsten Cherian et al.
5 citations
Abstract Introduction Ibogaine is an indole alkaloid traditionally used in spiritual and healing rites in some African cultures. Ibogaine is primarily studied in the context of substance dependence, but indications suggest it may enhance recovery from trauma. Here, we investigated the effects of ibogaine treatment for multisystem effects of exposure to repeated blasts and combat on...
Nature
May 1, 2023
Jianming Han, Jingying Zhang, Antonina L. Nazarova et al.
79 citations
The κ-opioid receptor (KOR) represents a highly desirable therapeutic target for treating not only pain but also addiction and affective disorders1. However, the development of KOR analgesics has been hindered by the associated hallucinogenic side effects2. The initiation of KOR signalling requires the Gi/o-family proteins including the conventional (Gi1, Gi2, Gi3, GoA and GoB) and...
Psychiatry Research Case Reports
April 26, 2023
Eric N. Kramer, Kalyn Reddy, Bryan Shapiro
7 citations
Several studies have been conducted and more are underway examining psilocybin-assisted therapy as a treatment for various psychiatric conditions including depressive disorders, anxiety disorders, and alcohol use disorder. However, many studies have been limited by small sample size and have not comprehensively evaluated treatment risks outside of controlled settings. To this point, we present...
Интеллект. Инновации. Инвестиции
April 24, 2023
Yu. A. Uymina
Osho Rajneesh is one of the most controversial neo–Hinduism teachers. Like in a mirror, Osho reflected the main ideas of his time, proclaimed those principles that are desirable and relevant for modern man. Despite Osho’s widespread fame, his significance as a spiritual leader and founder of the original religious and philosophical system, the significance of his teachings and ideas in the...