Life Science
October 5, 2023
Amjad Sohail
For thinking, brain activity occurs, yet not every area of our brain is active when we think about various things. There are significant ramifications for cognitive psychology and neuroscience from functional brain areas. It should enable us to apply neurophilosophical theories to the brain. This review aims to draw attention to neurophilosophy and its focus on fundamental problems in...
Life Science
May 1, 2023
Miroslav Adzic, Iva Lukic, Milos Mitic et al.
Major depressive disorder (MDD) afflicts approximately 5 % of the world population, and about 30-50 % of patients who receive classical antidepressant medications do not achieve complete remission (treatment resistant depressive patients). Emerging evidence suggests that targeting opioid receptors mu (MOP), kappa (KOP), delta (DOP), and the nociceptin/orphanin FQ receptor (NOP) may yield...
Life Science
March 27, 2021
Máira Tereza Talma Chírico, Mariana Reis Guedes, Lucas Gabriel Vieira et al.
In clinical and laboratory practice, the use of anesthetics is essential in order to perform surgeries. Anesthetics, besides causing sedation and muscle relaxation, promote several physiological outcomes, such as psychotomimetic alterations, increased heart rate, and blood pressure. However, studies depicting the behavioral effect induced by ketamine and isoflurane are conflicting. In the...
Life Science
July 24, 2013
Laura E. Halpin, Stuart A. Collins, Bryan K. Yamamoto
195 citations
Amphetamines are a class of psychostimulant drugs that are widely abused for their stimulant, euphoric, empathogenic and hallucinogenic properties. Many of these effects result from acute increases in dopamine and serotonin neurotransmission. Subsequent to these acute effects, methamphetamine and 3,4 methylenedioxymethamphetamine (MDMA) produce persistent damage to dopamine and serotonin nerve...
Life Science
July 24, 2013
M. Angoa-Perez, Michael J. Kane, Nieves Herrera-Mundo et al.
41 citations
Aims Mephedrone is a stimulant drug of abuse with close structural and mechanistic similarities to methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA). Although mephedrone does not damage dopamine nerve endings it increases the neurotoxicity of amphetamine, methamphetamine and MDMA. The effects of mephedrone on serotonin (5HT) nerve endings are not fully understood, with some...
Life Science
1989
J. Musacchio, M. Klein, P. Canoll
There is increasing evidence that sigma ligands and dextromethorphan (DM) bind to at least one common high-affinity site. DM and other antitussives do not produce psychotomimetic effects. This suggested that sigma ligands may produce their characteristic effects through another site, and prompted us to review critically the literature on the side effects of sigma opiates. Contrary to what is...