MRI is a noninvasive imaging technique that measures the neurological activity of a person’s brain over time. The BOLD signal, which represents variations in blood oxygenation associated with brain activity, is what it depends on.The investigation of functional connectivity emphasizes on the timevarying spontaneous variations in these BOLD signals. Functional connectivity measures the...
Disjunctivism is a much debated topic within present-day philosophy of perception. The pressing issue here is whether there is a fundamental difference in kind between perceptions and hallucinations. If a perception could counterfactually have been a hallucination with the same content, one can hardly claim that perceptions and hallucinations are fundamentally different in kind qua...
Post-detoxification phases of methamphetamine dependence are often characterized by neurophysiological instability, including tremors, insomnia, and anxiety, due to suppressed GABAergic activity and hyperdopaminergic rebound. Traditional Filipino distilled spirit, álak or lambanog, contains trace levels of ethanol and minor fusel alcohols which may exert mild GABA-A receptor agonism when...
This paper forwards the claim that our early human ancestors had protosacred experiences long before they had languages, architecture, or religions. A mountain may create feelings of awe while a grove in the forest may create feelings of serenity. In some circumstances (and very much dependent on the mental set of the individual), such protosacred experiences may create a sense of ultimacy that...
Abstract: This article applies approaches from current emotion research on material affective scaffolds—objects made and used to enhance, and more generally transform, affective states—to the emerging field of study focusing on emotions in ancient Near Eastern societies. Its main goal is to extend the framework of 4E cognition—with its central notion that human cognition is embodied, embedded,...
Disturbances of the minimal self, or anomalous self-experiences (ASEs), are increasingly regarded as a core feature of primary psychotic disorders (PPDs). However, it remains unclear whether similar self-disorders are present in substance-induced psychosis (SIP), a condition that often mimics PPDs in its early stages. The study aims to compare ASEs between PPD and SIP using the EASE interview,...
BACKGROUND: The use of psychedelics is currently increasing in the United States. Awareness of clinical trials investigating the therapeutic applications of psychedelics may result in a record number of people who use psychedelics for the first-time. This study aimed to develop a harm-reduction resource to facilitate safe and successful psychedelic experiences outside of regulated clinical and...
Psychedelics, acting primarily through 5-HT2A receptor binding and modulation of networks such as the default mode network (DMN), can induce shifts in self-perception, cognition, and emotion by promoting neuroplasticity and altering entrenched thought patterns. The biomedical model, emphasizing measurable neurochemical processes, often attempts to extract these neuroplastic benefits while...
Resonant Breathwork is proposed as a layered, measurable intervention that modulates vagal activity and interoceptive processing through acoustic vocalization, respiratory mechanics, and biofeedback. This review synthesizes human empirical studies from 2022–2025 across five domains: (1) noninvasive transcutaneous auricular vagus nerve stimulation and acoustic or vocal vagal engagement; (2)...
Psychedelics, such as psilocybin, reorganise large-scale brain connectivity, yet how these changes are reflected across electrophysiological (electroencephalogram, EEG) and haemodynamic (functional magnetic resonance imaging, fMRI) networks remains unclear. We present Brain-MGF, a multimodal graph fusion network for joint EEG-fMRI connectivity analysis. For each modality, we construct graphs...