Following decades of prohibition, psychedelic drugs have reemerged as promising therapeutics for stress-related conditions, including depression and post-traumatic stress disorder. Still, their impact on stress-related brain regions and the hypothalamic-pituitary-adrenal (HPA) axis remains unclear. This work explores the acute effects of psilocybin on the primary regulators of the HPA axis:...
Objective: To scope the available literature on antipsychotic treatment in substance-induced psychotic disorders, summarize evidence across substance categories, and highlight priorities for future research. Methods: This scoping review followed Arksey and O’Malley’s framework and PRISMA-ScR guidelines. A systematic search of PubMed, Scopus, Embase, PsycINFO, and Cochrane Library (January...
BACKGROUND: This study investigated pāramīs-based inner strengths and mental health outcomes among elderly Thai Buddhist meditators, with a particular focus on the combined effects of strict ethical adherence to the Five Precepts (abstaining from killing, stealing, sexual misconduct, lying, and intoxicants) and varying level of death contemplation practice because this combination is a hallmark...
Psilocybin, psilocin and the associated tryptamines are psychoactive alkaloids which are naturally biosynthesised by Psilocybe (Fr.) P.Kumm. fungi, commonly referred to as magic mushrooms. These psychoactive fungi were used traditionally in healing rituals, and are now being studied in clinical studies to investigate their benefits as a treatment for a number of mental health disorders. Since...
Phencyclidine (PCP), historically known as "angel dust," and its analogues (3-HO-PCP, 3-MeO-PCP, 4-MeO-PCP, 3-HO-PCE, 3-MeO-PCE, 4-MeO-PCE) are dissociative new psychoactive substances with high abuse potential and limited experimental safety data. An integrated in silico workflow (STopTox, admetSAR 3.0, ADMETlab 3.0, ACD/Labs Percepta, Toxtree, ProTox 3.0, OCHEM, TEST, VEGA QSAR) was applied...
Abstract In the Buddhist conceptualization of tanhā (a form of craving), it is seen as the main reason for suffering, the undermining of morals, and instability in existence. The goal of tanhā-nirodha (the cessation of craving) is Buddhist soteriology, but the goal is not limited to monastic practices and touches on many aspects of modern ethics, psychology, and social issues. In this paper,...
Cannabidiol (CBD) is a non-psychotomimetic phytocannabinoid constituent of the cannabis plant that shows promise for the treatment of a variety of neuropsychiatric disorders such as anxiety disorders, post-traumatic stress disorder, and substance use disorders. The nucleus accumbens (NAc) is a key brain region in the etiologies of these disorders and is actively modulated by CBD. Prior research...
Psilocybin holds promise as a treatment for mental illnesses. One dose of psilocybin induces structural remodeling of dendritic spines in the medial frontal cortex in mice. The dendritic spines would be innervated by presynaptic neurons, but the sources of these inputs have not been identified. Here, using monosynaptic rabies tracing, we map the brain-wide distribution of inputs to frontal...
Psychedelics are gaining recognition for their effectiveness as modulators of neuroplasticity in the treatment of a range of neuropsychiatric disorders. Psilocybin, lysergic acid diethylamide, N,N-dimethyltryptamine, and ketamine are substances that mainly affect the serotonergic and glutamatergic systems. They induce rapid synaptogenesis, dendritic remodeling, and changes in functional...
Understanding the neural correlates of consciousness remains a central challenge in neuroscience. In this study, we investigate the relationship between consciousness and neural responsiveness by analyzing intracranial electrocorticography recordings from nonhuman primates across three distinct states: wakefulness, anesthesia, and recovery. Using a nonequilibrium recurrent neural network (RNN)...