Addiction remains a major neuropsychiatric challenge, with dopaminergic, serotonergic, and GABAergic dysregulation underlying maladaptive behaviors. Traditional Brazilian medicinal plants offer a rich source of neuroactive compounds, yet their multi-target mechanisms remain underexplored. This study aimed to evaluate the neuropharmacological potential of harmine, caffeine, and damianin through...
Post-detoxification phases of methamphetamine dependence are often characterized by neurophysiological instability, including tremors, insomnia, and anxiety, due to suppressed GABAergic activity and hyperdopaminergic rebound. Traditional Filipino distilled spirit, álak or lambanog, contains trace levels of ethanol and minor fusel alcohols which may exert mild GABA-A receptor agonism when...