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Addiction: all studies

Page 246 of 859: studies 2,451 to 2,460 of 8,590, newest first. Back to the addiction overview

Research

Effects of LSD and Psilocybin on Heart Rate in Patients Receiving Psychedelic Treatment for Depressive and Anxiety Disorders: A Retrospective Observational Study

Psychology International December 19, 2025 Morgan C H Cheng, Tatiana Aboulafia Brakha, Albert Buchard et al.

Classic psychedelics such as lysergic acid diethylamide (LSD) and psilocybin induce mild cardiovascular activation in addition to their psychological effects. While these effects are well described in healthy adults, little is known about their dynamics in clinical populations undergoing psychedelic-assisted psychotherapy. This retrospective, observational, single-center study analyzed...

The Plausibility of Mind Uploading

Poligrafi December 18, 2025 Bojan Žalec

This article discusses the plausibility of uploading the human mind onto a non-biological digital medium. The concept of mind uploading has gained significant momentum due to advances in digital technology and artificial intelligence. This question is highly relevant for theology and religion because it addresses key theological issues. Undoubtedly, mind uploading conflicts with religious and...

The Soteriological Significance of Buddhānussati: Path to Liberation or Preliminary Practice

INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT December 18, 2025 Kumara Kumara

Abstract This research analyses the value of Buddhānussati (recollection of the Buddha) in Theravāda Buddhism, particularly its implications for soteriology, determining whether this form of meditation paves the way for attaining liberation (Nibbāna) or merely serves as a preliminary devotion. Although Buddhānussati holds a prominent position among the forty meditation objects (kammaṭṭhāna) in...

Ibogaine induces juvenile-like plasticity and modulates functional and structural regulators of plasticity in the adult mouse visual cortex

Research Square December 18, 2025 Alejo Acuña, Federico Billeri, Valentino Totaro et al. preprint

Abstract Background: Psychedelics have emerged as powerful modulators of neural plasticity, yet whether the atypical psychedelic ibogaine can enhance plasticity remains poorly understood. Here, we investigated whether a single administration of ibogaine can reinstate juvenile-like experience-dependent plasticity in the adult mouse visual cortex, a canonical model for studying neuroplasticity....

Dual Modulation of 5-HT2A Receptors and SERT by α-Ethyltryptamine and Its Optical Isomers.

ACS Chemical Neuroscience December 17, 2025 Justin M Silverman, Michael Fiorillo, Jason Younkin et al. 1 citation

α-Ethyltryptamine (AET), a synthetic tryptamine formerly used as an antidepressant, has resurfaced as a compound of interest due to its structural and functional overlap with serotonergic psychedelics and entactogens. Here, we characterized the pharmacological properties of racemic AET and its optical isomers, R(-)-AET and S(+)-AET, focusing on their interactions with the serotonin (or...

DOI: 10.1021/acschemneuro.5c00468 (opens in new tab) Full text (opens in new tab) 5-ht2a receptor G protein-coupled receptor Head-twitch response Psychedelics +3

Breaking the chains of depression: A systematic review and meta-analysis of psilocybin therapy

Journal of Affective Disorders December 17, 2025 Faheem Ahmed Khan, Nuruliarizki Shinta Pandupuspitasari, Tewin Tencomnao et al. 2 citations

Psilocybin, a naturally occurring hallucinogenic substance present in certain mushrooms, has drawn growing attention as a therapeutic breakthrough for several mental and psychiatric conditions. Psilocybin originated in spiritual and cultural traditions and has become the focus of extensive scientific research. This meta-analysis and systematic review aggregate results from the literature to...

Subjective Effects of Psychedelics Are the Plausible Mechanism of Psychedelic Moral Enhancement Rather than a Risk. Comment on Tang, B.L. Psychedelics for Moral Bioenhancement in Healthy Individuals—A Violation of the Non-Maleficence Principle? Psychoactives 2025, 4, 5

Psychoactives December 17, 2025 Juuso Kähönen 2 citations

In a recent Psychoactives article, Bor Luen Tang argues against psychedelic moral bioenhancement (PMBE)—the use of classic psychedelics such as psilocybin to foster moral growth in healthy individuals [...]

DOI: 10.3390/psychoactives4040043 (opens in new tab) Psilocybin Mechanism biology Consciousness Moral disengagement +3

The “Subjectica” Hypothesis: A Lateralized Neurophenomenological Model of Embodied Cognitive Dynamics

Preprints.org December 16, 2025 Deyan Shopin preprint

Contemporary accounts of hemispheric asymmetry in cognitive neuroscience predominantly emphasize neuroanatomical localization and functional specialization, while offering limited explanatory mechanisms for how lateralized neural processes become observable in embodied behavior. The Subjectica Hypothesis proposes a neurophenomenological framework in which hemispheric asymmetry is expressed not...

The effects of mindfulness on psychological thriving among urban park visitors: evidence from three experimental studies

Frontiers in Public Health December 16, 2025 Bingyan Meng, Jun Cao, Yunyun Wei et al. 1 citation

Amidst ongoing urbanization, understanding how to effectively enhance visitor well-being (e.g., Psychological Thriving) in accessible natural settings like urban parks is crucial. Mindfulness interventions offer a promising avenue, yet the comparative efficacy of different delivery modes (digital vs. traditional) and their underlying psychological pathways remain underexplored. Targeting this,...

Exploring Consciousness from the Inside

The MIT Press eBooks December 16, 2025 Stephen Fulder

Exploring Consciousness from the InsideStephen FulderConsciousness arises dependent on sense data and stimulation of the senses.Therefore it is dependent and has no self-existence.-Anguttara Nikaya 41:7 (Bodhi, 2012) Personal ReflectionsI have been interested in spiritual practice and inner exploration for most of my life.I can remember as a child, realizing that, like Mowgli in The Jungle...