Current Neurology and Neuroscience Reports
December 20, 2025
Robert Lawrence Kuhn
1 citation
To gather (almost) all (reasonable) theories of phenomenal consciousness, describe them neutrally (largely in the words of their authors), and organize them in a comprehensive, cross-disciplinary taxonomy of categories-"Landscape of Consciousness." Perhaps the process can encourage novel ways of thinking among medical (psychiatry/neurology) practitioners and neuroscientists. Landscape organizes...
iScience
December 19, 2025
Antonio Pazienti, Mariel Müller, Conrado A Bosman et al.
Slow-wave activity (SWA) is a hallmark of the loss of consciousness in non-REM sleep and anesthesia. The mechanistic underpinnings of SWA, and its evolution when transitioning toward the conscious brain state is poorly understood. We address this topic by recording multi-area and laminar activity in posterior parietal (PPC) and primary visual (V1) cortices of mice spontaneously awakening from...
Journal of Neuroscience
December 19, 2025
Nicolas G. Glynos, Emma R. Huels, Trent Groenhout et al.
11 citations
N,N-Dimethyltryptamine (DMT) is a serotonergic psychedelic that is being investigated for the treatment of psychiatric disorders. Although the neurophysiological effects of DMT in humans are well characterized, similar studies in animal models and data on the neurochemical effects of DMT are generally lacking, which are critical for a mechanistic understanding. Here, we combined behavioral...
Psychology International
December 19, 2025
Morgan C H Cheng, Tatiana Aboulafia Brakha, Albert Buchard et al.
Classic psychedelics such as lysergic acid diethylamide (LSD) and psilocybin induce mild cardiovascular activation in addition to their psychological effects. While these effects are well described in healthy adults, little is known about their dynamics in clinical populations undergoing psychedelic-assisted psychotherapy. This retrospective, observational, single-center study analyzed...
Poligrafi
December 18, 2025
Bojan Žalec
This article discusses the plausibility of uploading the human mind onto a non-biological digital medium. The concept of mind uploading has gained significant momentum due to advances in digital technology and artificial intelligence. This question is highly relevant for theology and religion because it addresses key theological issues. Undoubtedly, mind uploading conflicts with religious and...
INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT
December 18, 2025
Kumara Kumara
Abstract This research analyses the value of Buddhānussati (recollection of the Buddha) in Theravāda Buddhism, particularly its implications for soteriology, determining whether this form of meditation paves the way for attaining liberation (Nibbāna) or merely serves as a preliminary devotion. Although Buddhānussati holds a prominent position among the forty meditation objects (kammaṭṭhāna) in...
Research Square
December 18, 2025
Alejo Acuña, Federico Billeri, Valentino Totaro et al.
preprint
Abstract Background: Psychedelics have emerged as powerful modulators of neural plasticity, yet whether the atypical psychedelic ibogaine can enhance plasticity remains poorly understood. Here, we investigated whether a single administration of ibogaine can reinstate juvenile-like experience-dependent plasticity in the adult mouse visual cortex, a canonical model for studying neuroplasticity....
ACS Chemical Neuroscience
December 17, 2025
Justin M Silverman, Michael Fiorillo, Jason Younkin et al.
1 citation
α-Ethyltryptamine (AET), a synthetic tryptamine formerly used as an antidepressant, has resurfaced as a compound of interest due to its structural and functional overlap with serotonergic psychedelics and entactogens. Here, we characterized the pharmacological properties of racemic AET and its optical isomers, R(-)-AET and S(+)-AET, focusing on their interactions with the serotonin (or...
Journal of Affective Disorders
December 17, 2025
Faheem Ahmed Khan, Nuruliarizki Shinta Pandupuspitasari, Tewin Tencomnao et al.
2 citations
Psilocybin, a naturally occurring hallucinogenic substance present in certain mushrooms, has drawn growing attention as a therapeutic breakthrough for several mental and psychiatric conditions. Psilocybin originated in spiritual and cultural traditions and has become the focus of extensive scientific research. This meta-analysis and systematic review aggregate results from the literature to...
Psychoactives
December 17, 2025
Juuso Kähönen
2 citations
In a recent Psychoactives article, Bor Luen Tang argues against psychedelic moral bioenhancement (PMBE)—the use of classic psychedelics such as psilocybin to foster moral growth in healthy individuals [...]