Psychedelics are gaining attention as putative treatments for a range of psychiatric conditions, and evidence suggests that they produce sustained behavioural and clinical change. Enhanced learning is an emerging candidate mechanism mediating these sustained effects. This narrative review synthesises evidence across behavioural, neural and computational levels to examine the current evidence...
) that has a unique therapeutic potential across multiple indications, including opioid dependence, substance use disorders, depression, anxiety, posttraumatic stress disorder (PTSD), and traumatic brain injury (TBI). We systematically examined the effects of ibogaine, its main metabolite noribogaine, and a series of iboga analogs at monoamine neurotransmitter transporters, some of which have...
ABSTRACT Clinical trials suggest that a single dose of psilocybin is an effective treatment for substance use disorders (SUDs). Choice impulsivity is a value-based decision-making bias that predicts drug-intake escalation and is commonly associated with SUDs. The dorsomedial prefrontal cortex (dmPFC) regulates choice impulsivity and is enriched with 5-HT 2A receptors that mediate effects of...
This perspective paper explores the bidirectional influence between language emergence and the relational structure of subjective experiences, termed qualia structure, and lays out a constructive approach to the intricate dependency between the two. We hypothesize that the emergence of languages with distributional semantics (e.g., syntactic-semantic structures) is linked to the coordination of...
Abstract With the resurgence of psychedelic research and the growing interest in their therapeutic potential, there is an urgent need to understand how these compounds act across biological sexes. Despite widespread interest in their use for conditions marked by social impairments, including depression, anxiety, and anorexia nervosa, the influence of sex as a biological variable (SABV) on the...
The article is devoted to the relevant issue of rethinking the biblical concept of the «soul» in the context of modern scientific discoveries and challenges to traditional theological and philosophical understandings. It demonstrates an attempt to return to the biblical understanding of the «soul» through engagement with contemporary knowledge in the field of consciousness studies. It is shown...
Kendo is a martial art that embodies the Zen ideal and practices with bamboo swords, it shares similarities with fencing. Mindfulness is a mental state akin to Zen where one can observe sensations, feelings and thoughts as they happen while remaining impartial to them. Using fMRI of the auditory oddball task we investigated network connectivity based on Menon’s triple network theory and...
Background. The rapid integration of Brain-Computer Interfaces (BCIs) into human cognitive processes has initiated a profound transformation in how consciousness and personal identity are conceptualized. As neural data become digitized, the boundaries between human cognition and machine computation blur, leading to the emergence of what can be described as the algorithmic self a hybrid...
Recent evidence suggests that psychedelics hold promise in treating a range of neuropsychiatric disorders, highlighting the need to better understand their broader behavioral effects. Many animal-based behavioral assays related to mood, like anxiety and despair-like behavior, highly depend on locomotor activity. However, the influence of psychedelics on movement, especially in emotionally...
To gather (almost) all (reasonable) theories of phenomenal consciousness, describe them neutrally (largely in the words of their authors), and organize them in a comprehensive, cross-disciplinary taxonomy of categories-"Landscape of Consciousness." Perhaps the process can encourage novel ways of thinking among medical (psychiatry/neurology) practitioners and neuroscientists. Landscape organizes...