Psilocybin, a classic psychedelic compound, has garnered renewed interest as a potential treatment for various psychiatric disorders. This review provides a comprehensive overview of psilocybin's history, recent clinical evidence, ongoing clinical trials, neuroimaging findings, and regulations. Historically used in spiritual and healing rituals, psilocybin was in the early 1970s subjected to...
Ketergantungan pada ponsel pintar atau Nomophobia (No Mobile Phone Phobia) telah menjadi tantangan kesehatan mental yang signifikan bagi Generasi Z, termasuk siswa di lingkungan pesantren. Penelitian ini bertujuan untuk menguji efektivitas integrasi Islamic Mindfulness (Muraqabah) sebagai intervensi psikologis untuk menurunkan tingkat nomophobia pada siswa SMA Daruttaqwa Gresik. Muraqabah,...
Compatibilist theories of free will have traditionally reconciled freedom with causal determinism by redefining freedom in terms of rational responsiveness to reasons. While this dissolves the classical incompatibilist dilemma, it preserves a largely binary conception of agency: agents are either free or unfree depending on whether they possess rational capacities. This paper advances Graded...
Ketamine, an N-Methyl-D-aspartate receptor (NMDAR) antagonist, is used clinically as an anesthetic and antidepressant, and is also known for its psychotomimetic effects. Its impact on brain dynamics and behavior varies significantly with dosage likely via a dose-dependent modulation of the NMDARergic transmission. Currently, it is unclear how molecular changes at the microscopic level of NMDAR...
Astrocytes critically regulate states of consciousness, yet their molecular profiles across wake, sleep, and general anesthesia remain unclear. This study conducted proteomic and phosphoproteomic analyses of rat cortical astrocytes across these states using sevoflurane. Data quality was validated using principal component analysis (PCA) and Pearson correlation coefficient (PCC). Proteomics...
Based on findings in cross-lagged panel network (CLPN) models, Ma et al. concluded prospective effects between indicators of mindfulness and mental health problems. Here, we used multiverse methodology and found discrepant increasing, decreasing, and null effects depending on the used model, and meta-analytic aggregations of these discrepant effects did not differ significantly from zero....
Shel Silverstein’s The Giving Tree (1964) has long been read as a simple parable of unconditional giving and human desire. This comprehensive analysis proposes a far deeper reading: the tree as an embodiment of the Shekhinah, the feminine aspect of divine immanence in Kabbalistic theology, whose boundless generosity mirrors the mystical dynamics between God and creation. By juxtaposing this...
Over the past 15 years, psychedelic treatments have garnered substantial clinical interest, with psilocybin and 3,4-methylenedioxymethamphetamine (MDMA) advancing to phase 3 trials for various psychiatric conditions. This state-of-the-art review examines the evidence for these treatments and their proposed mechanisms of action, and identifies key challenges in clinical translation. Psychedelic...
Open MindFebruary 22, 2026Yoesoep Edhie Rachmad
preprint
The twenty-first century has produced a paradox unprecedented in human history: never before has humanity been so hyperconnected, yet never before has it experienced such widespread existential fragmentation. Digital networks collapse geographic distance, algorithmic systems personalize information flows, and virtual environments simulate immersive realities. Yet amid this technological...
The perception of God can be as a transcendent entity that is infinite and outside of human beings, typical for religious traditions, or as an immanent entity that is outside and inside of human beings, typical for mystical traditions. These different perceptions of God may be associated with different neural correlates depending on which God we pray to. To elucidate the neural correlates of...