Michelle Kokkinou

2 papers in the library · 254 citations · publishing 2017-2026

Papers

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Acute cannabidiol (CBD), tetrahydrocannabinol (THC) and their mixture (THC:CBD) exert differential effects on brain activity and blood flow in rats: A translational neuroimaging study.

Journal of Psychopharmacology March 1, 2026 Eilidh Macnicol, Michelle Kokkinou, Maria Elisa Serrano Navacerrada et al. 2 citations

Cannabis constituents, including Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), show distinct pharmacological profiles with therapeutic relevance for neurological and psychiatric conditions. THC exerts euphoric effects primarily via CB1 receptor activation, while CBD displays non-euphoric properties affecting various pathways. This study evaluated the effects of THC, CBD, and their...

DOI: 10.1177/02698811251360745 Full text Cannabinoids Cerebral blood flow Neuroimaging Rat +1

The effects of ketamine on dopaminergic function: meta-analysis and review of the implications for neuropsychiatric disorders

Molecular Psychiatry October 3, 2017 Michelle Kokkinou, Abhishekh Hulegar Ashok, Oliver Howes 252 citations

Ketamine is a non-competitive antagonist at the N -methyl- d -aspartate receptor. It has recently been found to have antidepressant effects and is a drug of abuse, suggesting it may have dopaminergic effects. To examine the effect of ketamine on the dopamine systems, we carried out a systematic review and meta-analysis of dopamine measures in the rodent, human and primate brain following acute...

DOI: 10.1038/mp.2017.190 Full text