This work aims to assess the S65487-induced disruption of the B-cell lymphoma-2 (Bcl2)/Bcl2-like protein 11 (Bim) complex at therapeutic doses via a pharmacokinetic/pharmacodynamic model and to reconcile pharmacokinetic data from microdoses and therapeutic doses in a single population pharmacokinetic model. The first model consists of a linear 3-compartment pharmacokinetic model linked to an...
This paper explores the metaphysics of consciousness through the lens of Mādhva Gauḍīya Vedānta, a Hindu philosophical tradition within Caitanya Vaiṣṇavism. It primarily examines how this school’s concepts relate to contemporary cosmopsychism. While resonating with cosmopsychist views of universal consciousness, the Gauḍīya perspective maintains a dualist metaphysics. It posits the jīvātmā as...
This paper develops the thesis that the decisive discontinuity in nature was not first the emergence of life and then, separately, the emergence of consciousness, but rather the invention of the boundary: the appearance of a membrane that separated an interior from an exterior. A bounded system is no longer a mere portion of matter among other portions of matter. It becomes a unit whose...
Psychedelics have re-emerged as promising therapeutics for neuropsychiatric disorders, including depression, anxiety, post-traumatic stress disorder, and substance use disorders. While their beneficial effects are largely attributed to serotonin 2A (5-HT2A) receptor activation, psychedelics exhibit substantial diversity in chemical structure, receptor binding kinetics, metabolism, and duration...
Zebrafish larvae are increasingly used in behavioural pharmacology because of their translational relevance and suitability for anxiety- and stress-related studies. However, it remains unclear whether commonly used behavioural assays and molecular stress markers provide convergent evidence of anxiolytic-like drug activity. This study therefore aimed not to validate a single predictive screening...
PsyArXivJune 16, 2026Ido Shalev, Emily Hayun, Alal Eran et al.
preprint
Whether a person feels overwhelmed by others' emotions or remains detached from them may depend not on how much empathy they have, but on the balance between the cognitive and emotional components of empathy. An imbalance between emotional and cognitive empathy, termed empathic disequilibrium, has consistently distinguished clinical from non-clinical groups across a range of conditions,...
EpilepsiaJune 16, 2026Shweta Soni, Karine Brochu, Paolo Federico et al.
Meditation has widely recognized psychological and neuromodulatory benefits, yet its effects on epileptiform activity remain unclear. This study examined whether novice meditation modulates interictal epileptiform discharges (IEDs) in patients with drug-resistant epilepsy using intracranial electroencephalography (iEEG). Twenty-seven meditation-naïve patients undergoing iEEG monitoring...
OBJECTIVES: Ecstasy is commonly abused due to entactogenic effects. Although our previous studies on isolated perfused rat model confirmed inhibition of CYP2D6 by MDMA, the time for enzyme recovery was different when mirtazapine and tramadol were used as substrates. Therefore, present study intended to investigate CYP2D6 inhibition by MDMA using dextromethorphan as a well-known probe. Two...
Objective: Current treatments for schizophrenia (SZ) are often not effective for all symptoms, with sex-dependent effects poorly understood. Cannabidiol (CBD) and sodium nitroprusside (SNP) have emerged as potential prophylactic options. We evaluated their efficacy in preventing positive, negative, and cognitive deficits in a ketamine (KET) rodent model of SZ in both sexes. Methods: Wistar rats...
Schizophrenia ResearchJune 16, 2026David Olivares-Berjaga, Natàlia Rodríguez, Albert Martínez-pinteño et al.
Schizophrenia (SZ) is a neurodevelopmental disorder involving excitatory/inhibitory imbalance and apoptotic dysregulation. VDAC1, a voltage-dependent anion channel protein located in the mitochondrial outer membrane, plays a pivotal role in mitochondria-mediated apoptosis. However, its involvement in SZ remains underexplored. This study aimed to investigate VDAC1 protein levels in the...