Biomedicine & Pharmacotherapy - The Consciousness Library

Enhanced dopamine transporter binding is associated with species-specific 2C-B-induced reinforcement in marmosets, but not in mice

Biomedicine & Pharmacotherapy July 29, 2026 Yong-Qing Zhang, Hyeokjun Kwon, Taeyun Yoo et al.

Hallucinogens have been prescribed for the treatment of mental illnesses; however, reports on the dependence potential of hallucinogens across species remain inconsistent. Non-human primate (NHP) self-administration model are suitable for evaluating species-specific reinforcement behavior induced by hallucinogens. In this study, we demonstrated that 4-bromo-2,5-dimethoxyphenethylamine (2C-B)...

DOI: 10.1016/j.biopha.2026.119773

Anxiety-related platform in zebrafish (Danio rerio) larvae: An integrated analysis of behavioural and molecular assay in drug screening research

Biomedicine & Pharmacotherapy June 17, 2026 Małgorzata Potoczna, Natalia Kasica, Małgorzata Chmielewska-Krzesińska et al.

Zebrafish larvae are increasingly used in behavioural pharmacology because of their translational relevance and suitability for anxiety- and stress-related studies. However, it remains unclear whether commonly used behavioural assays and molecular stress markers provide convergent evidence of anxiolytic-like drug activity. This study therefore aimed not to validate a single predictive screening...

DOI: 10.1016/j.biopha.2026.119680 Zebrafish Drug discovery Screening techniques Phenotypic screening +4

Ibogalogs improve spatial and recognition memory in rodents through a mechanism involving 5-HT2A receptor activation-enhanced NMDA receptor activity in hippocampal pyramidal CA1 neurons

Biomedicine & Pharmacotherapy November 13, 2025 Abdeslam Chagraoui, Luis A Haro Santillan, Renata Bocian et al. 5 citations

This study evaluated the effects of ibogalogs on recognition and spatial memory in rodents, focusing on potential hippocampal mechanisms. The Barnes maze study demonstrated that ibogaminalog (DM506) and ibogainalog (IBG) improved short- (30 min) and long-term (24 and 72 h) spatial memory in mice, whereas tabernanthalog (TBG) showed less efficacy. The novel object recognition task (NORT) results...

DOI: 10.1016/j.biopha.2025.118742 Hippocampal formation Nmda receptor Hippocampus Glutamate receptor +9

Psilocybin as a fast-acting and long-lasting antidepressant for adolescence: Proposing NeuroD1 as a biomarker of its long-term plasticity

Biomedicine & Pharmacotherapy October 30, 2025 Rubén García‐cabrerizo, Itziar Beruete-Fresnillo, Pedro Bergas-Cladera et al. 3 citations

Adolescent depression is a significant public health concern, yet treatment options remain limited, particularly due to age- and sex-related differences in antidepressant efficacy. This study explored for the first time the potential antidepressant-like response of psilocybin in adolescence by examining acute, repeated and persistent effects in Sprague-Dawley rats of both sexes, as measured...

DOI: 10.1016/j.biopha.2025.118720 Psilocybin Neurogenesis Neuroplasticity Antidepressant +6

Present and future of metabolic and metabolomics studies focused on classical psychedelics in humans

Biomedicine & Pharmacotherapy December 31, 2023 David Fabregat-Safont, Alex Gomez-Gomez, Francisco Madrid-Gambin et al.

Psychedelics are classical hallucinogen drugs that induce a marked altered state of consciousness. In recent years, there has been renewed attention to the possible use of classical psychedelics for the treatment of certain mental health disorders. However, further investigation to better understand their biological effects in humans, their mechanism of action, and their metabolism in humans is...

DOI: 10.1016/j.biopha.2023.115775. Full text Psilocybin DMT Psychedelic Compounds LSD Hallucinogens +16

Serotonin 5-HT2A, 5-HT2c and 5-HT1A receptor involvement in the acute effects of psilocybin in mice. In vitro pharmacological profile and modulation of thermoregulation and head-twich response

Biomedicine & Pharmacotherapy August 29, 2022 Ines Erkizia-Santamaría, R. Alles-Pascual, Igor Horrillo et al. 108 citations

The psychedelic 5-HT2A receptor (5HT2AR) agonist psilocybin (or the active metabolite psilocin) has emerged as potential useful drug for various neuropsychiatric diseases, with a rapid onset of therapeutic activity. However, the mechanisms responsible for such effects remain incompletely characterized. We aimed to study in vitro pharmacological profile and in vivo acute mechanism of...

DOI: 10.1016/j.biopha.2022.113612 Psilocybin Serotonin Pharmacology Hallucinogen +5

Metabolomics and integrated network analysis reveal roles of endocannabinoids and large neutral amino acid balance in the ayahuasca experience

Biomedicine & Pharmacotherapy March 24, 2022 Francisco Madrid-Gambin, Alex Gomez-Gomez, Arnau Busquets-García et al. 14 citations

There has been a renewed interest in the potential use of psychedelics for the treatment of psychiatric conditions. Nevertheless, little is known about the mechanism of action and molecular pathways influenced by ayahuasca use in humans. Therefore, for the first time, our study aims to investigate the human metabolomics signature after consumption of a psychedelic, ayahuasca, and its connection...

DOI: 10.1016/j.biopha.2022.112845 Ayahuasca Metabolomics Pharmacology

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