PsyArXivJune 16, 2026Ido Shalev, Emily Hayun, Alal Eran et al.
preprint
Whether a person feels overwhelmed by others' emotions or remains detached from them may depend not on how much empathy they have, but on the balance between the cognitive and emotional components of empathy. An imbalance between emotional and cognitive empathy, termed empathic disequilibrium, has consistently distinguished clinical from non-clinical groups across a range of conditions,...
EpilepsiaJune 16, 2026Shweta Soni, Karine Brochu, Paolo Federico et al.
Meditation has widely recognized psychological and neuromodulatory benefits, yet its effects on epileptiform activity remain unclear. This study examined whether novice meditation modulates interictal epileptiform discharges (IEDs) in patients with drug-resistant epilepsy using intracranial electroencephalography (iEEG). Twenty-seven meditation-naïve patients undergoing iEEG monitoring...
OBJECTIVES: Ecstasy is commonly abused due to entactogenic effects. Although our previous studies on isolated perfused rat model confirmed inhibition of CYP2D6 by MDMA, the time for enzyme recovery was different when mirtazapine and tramadol were used as substrates. Therefore, present study intended to investigate CYP2D6 inhibition by MDMA using dextromethorphan as a well-known probe. Two...
Objective: Current treatments for schizophrenia (SZ) are often not effective for all symptoms, with sex-dependent effects poorly understood. Cannabidiol (CBD) and sodium nitroprusside (SNP) have emerged as potential prophylactic options. We evaluated their efficacy in preventing positive, negative, and cognitive deficits in a ketamine (KET) rodent model of SZ in both sexes. Methods: Wistar rats...
Schizophrenia ResearchJune 16, 2026David Olivares-Berjaga, Natàlia Rodríguez, Albert Martínez-pinteño et al.
Schizophrenia (SZ) is a neurodevelopmental disorder involving excitatory/inhibitory imbalance and apoptotic dysregulation. VDAC1, a voltage-dependent anion channel protein located in the mitochondrial outer membrane, plays a pivotal role in mitochondria-mediated apoptosis. However, its involvement in SZ remains underexplored. This study aimed to investigate VDAC1 protein levels in the...
This project is a scoping review examining the current evidence base for psilocybin-assisted therapy across depression, anxiety disorders, substance use disorders, and their comorbid presentations. The review aims to map the scope of existing research, summarise reported therapeutic outcomes, and evaluate the methodological quality of the evidence base. The full study rationale, objectives,...
Research Problem: The development of artificial intelligence (AI) functions as an unprecedented mirror, reflecting remarkable capacities yet fundamental limitations of human nature across philosophical, ethical, metaphysical, and spiritual dimensions. Method: Adopting a critical correlation methodology, the study conducts a systematic textual analysis of primary Qur’ānic and classical Islamic...
This scoping review aims to comprehensively map and synthesize the breadth of evidence from original research on the relationship between psilocybin and health, spanning clinical trials, epidemiological surveys, mechanistic experiments, and cross-sectional attitudinal studies. The review uses 145 references and builds its evidence map from 216 original studies with 271241797 total...
Introduction: Contemporary psychiatry is grappling with a profound stagnation in innovation. It is primarily relying on the chronic management of symptoms through traditional daily-dose pharmacotherapy. The emergence of psychedelics and ketamine marks a significant departure from this model. It is offering rapid-acting, interventional alternatives that target the underlying neurobiological...
Recent studies have shown promising results for psychedelics in the treatment of psychiatric disorders. Both in clinical and recreational settings, contextual elements, such as music, can influence the experience of users and may be linked to positive outcomes. This systematic review identifies how music is being selected and used in psychedelisc-assisted psychotherapy (PAP). The search adopted...