Trigeminal neuralgia (TN) is a debilitating orofacial pain condition frequently complicated by anxiety and depression, forming a self-reinforcing pain-affect cycle with limited therapeutic options. A TN mouse model with anxiety-like behavior was established using partial infraorbital nerve transection (pIONT). Esketamine (ES) (5 or 10 mg/kg) was administered intraperitoneally from postoperative...
Depression-like behavior is closely associated with neuroinflammation. Lipopolysaccharide (LPS) can activate N-methyl-d-aspartate receptors and induce cellular pyroptosis and neuroinflammation, thereby triggering depression-like behavior in animals. The ketamine metabolite (2R,6R)-hydroxynorketamine (HNK) exerts significant antidepressant-like effects without the adverse effects associated with...
Background: Shared psychotic disorder (folie à deux), first described by Lasègue and Falret in 1877, refers to the transmission of delusional beliefs from a dominant individual to a closely associated secondary, usually in the context of social isolation (1). Although it is no longer a distinct entity in DSM-5 or ICD-11 (2,3), it remains clinically significant, particularly among dyads with...
Generation Z is a generation born and raised in the digital era, making technology an inseparable part of their daily lives. While technological advancements provide easier access to information and spiritual resources, they also present challenges such as digital distractions, digital addiction, diminished capacity for reflection, and increasing psychological and spiritual pressures. This...
This chapter explores the profound possibility of mind uploading, the theoretical process of transferring human minds from biological brains to digital hardware. It examines the ‘whole brain emulation’ roadmap, which involves scanning the brain&s;s detailed structure and recreating its causal interactions within a computer simulation. The discussion highlights two critical philosophical...
Recent advances in neuropsychopharmacology have renewed interest in psychedelics and entactogens as potential treatments for brain disorders, owing to their rapid effects on neural plasticity, cognition, and affect. Classical serotonergic psychedelics primarily act as 5-HT2A receptor agonists with additional activity at 5-HT1A and other serotonin receptors, whereas entactogens such as MDMA...
『GeumoSinhwa』 and 『GijaeGiui』 are works that intensively feature the figures of visitors to the transcendent world from the era of tales. These visitors challenge the ontology of immortality not through variations of the ‘body,’ but through the experiment of ‘'crossing boundaries with the physical body itself.’ The aspects of visitors to the transcendent world in classical novels manifest as...
Bacteria are constantly exposed to stress, which intensifies as cells age, nutrients are depleted, and metabolite levels change. As metabolic activity increases, the cytoplasm transitions from a glass-like to a more fluid state, supporting the stochastic (spontaneous) and chaotic (nonlinear and unpredictable) movement of particles. The rate at which suspended particles or those in vacuole-like...
Background: Global displacement is a major public mental health concern shaped by conflict, protracted geopolitical instability, disrupted social worlds, and structural inequities. Yoga is increasingly discussed within health promotion as a potentially accessible and adaptable practice. However, much of the existing literature has prioritized symptom-based outcomes and has rarely been situated...
Background. In modern psychology, mindfulness is regarded as a multidimensional psychological phenomenon associated with the deliberate direction of attention to present-moment experience, an open, accepting, and non-judgmental attitude toward that experience, the development of self-regulation and psychological flexibility, and a reduction in automatic emotional and behavioral reactivity....