This project is a scoping review examining the current evidence base for psilocybin-assisted therapy across depression, anxiety disorders, substance use disorders, and their comorbid presentations. The review aims to map the scope of existing research, summarise reported therapeutic outcomes, and evaluate the methodological quality of the evidence base. The full study rationale, objectives,...
Research Problem: The development of artificial intelligence (AI) functions as an unprecedented mirror, reflecting remarkable capacities yet fundamental limitations of human nature across philosophical, ethical, metaphysical, and spiritual dimensions. Method: Adopting a critical correlation methodology, the study conducts a systematic textual analysis of primary Qur’ānic and classical Islamic...
This scoping review aims to comprehensively map and synthesize the breadth of evidence from original research on the relationship between psilocybin and health, spanning clinical trials, epidemiological surveys, mechanistic experiments, and cross-sectional attitudinal studies. The review uses 145 references and builds its evidence map from 216 original studies with 271241797 total...
Introduction: Contemporary psychiatry is grappling with a profound stagnation in innovation. It is primarily relying on the chronic management of symptoms through traditional daily-dose pharmacotherapy. The emergence of psychedelics and ketamine marks a significant departure from this model. It is offering rapid-acting, interventional alternatives that target the underlying neurobiological...
Recent studies have shown promising results for psychedelics in the treatment of psychiatric disorders. Both in clinical and recreational settings, contextual elements, such as music, can influence the experience of users and may be linked to positive outcomes. This systematic review identifies how music is being selected and used in psychedelisc-assisted psychotherapy (PAP). The search adopted...
Abstract This paper advances and defends an inclusive functionalist conception of perception, according to which any cognitive process that involves information selection, representation—understood in a functional sense as an internal state that carries information about the world and guides behavior and cognition independently of its phenomenal properties—and behavioral guidance qualifies as...
Scientific ReportsJune 14, 2026Bar Eilat Yogev, Gal Levi, Noa Efroni et al.
Alcohol consumption before trauma is a prevalent but understudied risk factor for posttraumatic stress disorder (PTSD). This study investigated whether acute ethanol exposure prior to trauma modulates PTSD-like symptom development in rats, identified hippocampal mechanisms involved, and tested an early post-trauma intervention. Adult male Sprague-Dawley rats received ethanol (1.6 g/kg, 40% v/v,...
Metabolic EngineeringJune 14, 2026Zachary N. Abrahms, Mohammad Majdi, Siena M. Madsen et al.
Stable, high-level biosynthesis of complex natural products requires precise control of heterologous pathway expression, yet transcriptional architectures optimized on plasmids often fail when transferred to the chromosome. Here, we present ePathIntegrate, a genome-centric pathway engineering strategy that leverages CRISPR-associated transposases (CASTs) to integrate and rebalance multigene...
PsyArXivJune 13, 2026Sophie Hascher, Anoushka Parylo, Mike Kendig et al.
preprint
Mindfulness-based treatments have demonstrated efficacy in reducing addictive behaviours, including food addiction. Yet, accessibility to in-person programmes remains a barrier, with limited capacity issues and accessibility for individuals suffering from mobility impairment. Virtual reality (VR) offers a promising platform to deliver mindfulness interventions in immersive nature-like...
A common objection to artificial or simulated consciousness is that a simulated brain is no more conscious than simulated water is wet. We address this from the perspective of Intrinsic Computational Functionalism (ICF): if consciousness is computationally constituted, it depends not on externally imposed descriptions but on the computational structures a system physically realizes in virtue of...