Research published in British Journal of Pharmacology

Pharmacological comparison of the effect of ibogaine and 18-methoxycoronaridine on isolated smooth muscle from the rat and guinea-pig.

British Journal of Pharmacology April 1, 2000 M K Mundey, N A Blaylock, R Mason et al. 6 citations

Ibogaine and 18-methoxycoronaridine are naturally occurring alkaloids reported to possess antiaddictive properties in several models of drug dependence. We have examined their effect at mu-opioid receptors regulating neurogenic contractions of several smooth muscle preparations and also against spontaneous contractions of the rat isolated portal vein. Ibogaine (pIC(50) 5.28) and...

DOI: 10.1038/sj.bjp.0703227 Full text Ibogaine Smooth muscle Purinergic signaling Pharmacology

Investigation of the prejunctional α2‐adrenoceptor mediated actions of MDMA in rat atrium and vas deferens

British Journal of Pharmacology November 1, 1999 Aisling Lavelle, Valerie Honner, James R. Docherty 55 citations

We have investigated the effects of methylenedioxymethamphetamine (MDMA, ‘ecstasy’) on peripheral noradrenergic neurotransmission in the rat. In rat atrial slices pre‐incubated with [ 3 H]‐noradrenaline and in the presence of desipramine (1 μ M ) to prevent effects of MDMA on basal outflow of tritium, MDMA (10 μ M ) significantly inhibited the release of tritium evoked by short trains of six...

DOI: 10.1038/sj.bjp.0702875 MDMA Yohimbine Vas deferens Endocrinology +6

Modulation by fluoxetine of striatal dopamine release following Delta9-tetrahydrocannabinol: a microdialysis study in conscious rats.

British Journal of Pharmacology September 1, 1999 D T Malone, D A Taylor

1. The present study was undertaken to investigate the effect of Delta9-tetrahydrocannabinol (Delta9-THC) and possible serotoninergic involvement on the extracellular level of dopamine (DA) in the striatum using microdialysis in conscious, freely-moving rats. 2. A dose-dependent increase in striatal DA release occurred after i.v. administration of 0.5 - 5 mg kg-1 Delta9-THC when compared with...

DOI: 10.1038/sj.bjp.0702753 Full text

Studies on the role of dopamine in the degeneration of 5‐HT nerve endings in the brain of Dark Agouti rats following 3,4‐methylenedioxymethamphetamine (MDMA or ‘ecstasy’) administration

British Journal of Pharmacology February 1, 1999 María Isabel Colado, Esther O’shea, R Granados et al. 82 citations

We investigated whether dopamine plays a role in the neurodegeneration of 5‐hydroxytryptamine (5‐HT) nerve endings occurring in Dark Agouti rat brain after 3,4‐methylenedioxymethamphetamine (MDMA or ‘ecstasy’) administration. Haloperidol (2 mg kg −1 i.p.) injected 5 min prior and 55 min post MDMA (15 mg kg −1 i.p.) abolished the acute MDMA‐induced hyperthermia and attenuated the neurotoxic loss...

DOI: 10.1038/sj.bjp.0702373 MDMA Ecstasy Microdialysis Dopamine +7

Role of hyperthermia in the protective action of clomethiazole against MDMA (‘ecstasy’)‐induced neurodegeneration, comparison with the novel NMDA channel blocker AR‐R15896AR

British Journal of Pharmacology June 1, 1998 María Isabel Colado, R Granados, Esther O’shea et al. 80 citations

The immediate effect of administration of 3,4‐methylenedioxymethamphetamine (MDMA or ‘ecstasy’) on rectal temperature and the effect of putative neuroprotective agents on this change has been examined in rats. The influence of the temperature changes on the long term MDMA‐induced neurodegeneration of cerebral 5‐hydroxytryptamine (5‐HT) nerve terminals was also examined. The novel low affinity...

DOI: 10.1038/sj.bjp.0701859 MDMA Ecstasy Pharmacology Nmda receptor +8

In vivo evidence for free radical involvement in the degeneration of rat brain 5‐HT following administration of MDMA (‘ecstasy’) and p‐chloroamphetamine but not the degeneration following fenfluramine

British Journal of Pharmacology July 1, 1997 María Isabel Colado, Esther O’shea, R Granados et al. 175 citations

Administration of 3,4‐methylenedioxymethamphetamine (MDMA or ‘ecstasy’) to several species results in a long lasting neurotoxic degeneration of 5‐hydroxytryptaminergic neurones in several regions of the brain. We have now investigated whether this degeneration is likely to be the result of free radical‐induced damage. Free radical formation can be assessed by measuring the formation of 2,3‐ and...

DOI: 10.1038/sj.bjp.0701213 MDMA Ecstasy Serotonin Serotonergic +12

A study of the neurotoxic effect of MDMA (‘ecstasy’) on 5‐HT neurones in the brains of mothers and neonates following administration of the drug during pregnancy

British Journal of Pharmacology June 1, 1997 María Isabel Colado, Esther O’shea, R Granados et al. 176 citations

It is well established that 3,4‐methylenedioxymethamphetamine (MDMA or ‘ecstasy’) is neurotoxic and produces long term degeneration of cerebral 5‐hydroxytryptamine (5‐HT) nerve terminals in many species. Since MDMA is used extensively as a recreational drug by young people, it is being ingested by many women of child bearing age. We have therefore examined the effect of administering high doses...

DOI: 10.1038/sj.bjp.0701201 MDMA Ecstasy Serotonin Endocrinology +11

Neurochemical and behavioural interactions between ibogaine and nicotine in the rat.

British Journal of Pharmacology February 1, 1996 M E Benwell, P E Holtom, R J Moran et al. 40 citations

1. In vivo brain microdialysis has been employed to investigate the effects of ibogaine on nicotine-induced changes in dopamine overflow in the nucleus accumbens (NAc) of freely moving rats. The effects of the compound on locomotor responses to nicotine and behaviour in the elevated plus-maze were also examined. 2. No changes were observed in the dopamine overflow or the locomotor activity of...

DOI: 10.1111/j.1476-5381.1996.tb15253.x Full text

The hyperthermic and neurotoxic effects of ‘Ecstasy’ (MDMA) and 3,4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype

British Journal of Pharmacology August 1, 1995 María Isabel Colado, Jodi L. Williams, A.r. Green 165 citations

1. The effect of administration of 3,4-methylenedioxymethamphetamine (MDMA or 'Ecstasy') and its N-demethylated product, 3,4-methylenedioxyamphetamine (MDA) on both rectal temperature and long term neurotoxic loss of cerebral 5-hydroxytryptamine (5-HT) has been studied in male and female Dark Agouti (DA) rats. The female metabolizes debrisoquine more slowly than the male and its use has been...

DOI: 10.1111/j.1476-5381.1995.tb15037.x MDMA Ecstasy Serotonin Debrisoquine +3

A study of the mechanism of MDMA (‘Ecstasy’)‐induced neurotoxicity of 5‐HT neurones using chlormethiazole, dizocilpine and other protective compounds

British Journal of Pharmacology 1994 María Isabel Colado, A.r. Green 62 citations

1. An investigation has been made in rats into the neurotoxic effect of the relatively selective 5-hydroxytryptamine (5-HT) neurotoxin, 3,4-methylenedioxymethamphetamine (MDMA or 'Ecstasy') using chlormethiazole and dizocilpine, both known neuroprotective compounds and also gamma-butyrolactone, ondansetron and pentobarbitone. 2. Administration of MDMA (20 mg kg-1, i.p.) resulted in a 50% loss...

DOI: 10.1111/j.1476-5381.1994.tb14034.x MDMA Ecstasy Serotonin Dizocilpine +5

5‐HT loss in rat brain following 3, 4‐methylenedioxymethamphetamine (MDMA), p‐chloroamphetamine and fenfluramine administration and effects of chlormethiazole and dizocilpine

British Journal of Pharmacology March 1, 1993 María Isabel Colado, Tracey K. Murray, A.r. Green 133 citations

1. The present study has investigated whether the neurotoxic effects of the relatively selective 5-hydroxytryptamine (5-HT) neurotoxins, 3,4-methylenedioxymethamphetamine (MDMA or 'Ecstasy'), p-chloroamphetamine (PCA) and fenfluramine on hippocampal and cortical 5-HT terminals in rat brain could be prevented by administration of either chlormethiazole or dizocilpine. 2. Administration of MDMA...

DOI: 10.1111/j.1476-5381.1993.tb12846.x MDMA Serotonin Dizocilpine P-chloroamphetamine +6

Behavioural evidence for a functional interaction between central 5-HT2 and 5-HT1A receptors.

British Journal of Pharmacology August 1, 1990 L I Backus, Trevor Sharp, D G Grahame-Smith

1. The possibility of 5-HT2 receptor modulation of central 5-HT1A receptor function has been examined using the 5-hydroxytryptamine (5-HT) behavioural syndrome induced by 5-HT1A receptor active drugs in rats. 2. The 5-HT2/5-HTIC antagonist ritanserin (0.1-2 mg kg-1) increased the 5-HT behavioural syndrome induced by submaximally effective doses of 8-hydroxy-2-(di-n-propylamino)tetralin...

DOI: 10.1111/j.1476-5381.1990.tb14094.x Full text

An in vivo dialysis and behavioural study of the release of 5-HT by p-chloroamphetamine in reserpine-treated rats.

British Journal of Pharmacology May 1, 1989 A Adell, G S Sarna, P H Hutson et al. 77 citations

1. Reserpine (2.5 mg kg-1 i.p.) decreased rat brain 5-hydroxytryptamine (5-HT) by 86% 24 h later but most components of the 5-HT-dependent behavioural syndrome induced by p-chloroamphetamine (PCA, 5 mg kg-1 i.p.) or 5-methoxy-N,N-dimethyltryptamine (5-MeODMT, 5 mg kg-1 i.p.) over 1 h after administration were unaffected. However, Straub tail was increased after giving PCA or 5-MeODMT and head...

DOI: 10.1111/j.1476-5381.1989.tb11943.x Full text

5-Methoxy-N,N-dimethyltryptamine-induced analgesia is blocked by alpha-adrenoceptor antagonists in rats.

British Journal of Pharmacology October 1, 1986 T Archer, W Danysz, G Jonsson et al. 16 citations

The effects of the alpha-adrenoceptor antagonists prazosin, phentolamine and yohimbine upon 5-methoxy-N,N-dimethyltryptamine (5-MeODMT)-induced analgesia were tested in the hot-plate, tail-flick and shock-titration tests of nociception with rats. Intrathecally injected yohimbine and phentolamine blocked or attenuated the analgesia produced by systemic administration of 5-MeODMT in all three...

DOI: 10.1111/j.1476-5381.1986.tb10259.x Full text

The effects of monoamine oxidase inhibitors on the ejaculatory response induced by 5-methoxy-N,N-dimethyltryptamine in the rat.

British Journal of Pharmacology August 1, 1986 L Rényi 10 citations

The ejaculatory response and other components of the 5-hydroxytryptamine (5-HT) behavioural syndrome induced by 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) (3 mg kg-1, i.p.) were studied following single and repeated treatment of rats with eight different monoamine oxidase (MAO) inhibitors. Single and repeated treatment with the 5-HT agonist 5-MeODMT, and with low doses of the potent releaser...

DOI: 10.1111/j.1476-5381.1986.tb16256.x Full text

The effect of selective 5-hydroxytryptamine uptake inhibitors on 5-methoxy-N,N-dimethyltryptamine-induced ejaculation in the rat.

British Journal of Pharmacology April 1, 1986 L Rényi 39 citations

The ejaculatory response and the 5-hydroxytryptamine (5-HT) behavioural syndrome induced by 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) (3 mg kg-1 i.p.) were studied following acute and repeated treatment of rats with the selective uptake inhibitors of 5-HT, fluoxetine, zimeldine, alaproclate, and citalopram. The oral doses used were based on the respective ED50 values for uptake inhibition....

DOI: 10.1111/j.1476-5381.1986.tb14580.x Full text

The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate

British Journal of Pharmacology June 1, 1983 Nabil A. Anis, Stephen C. Berry, N.r. Burton et al. 1,415 citations

The interaction of two dissociative anaesthetics, ketamine and phencyclidine, with the responses of spinal neurones to the electrophoretic administration of amino acids and acetylcholine was studied in decerebrate or pentobarbitone-anaesthetized cats and rats. Both ketamine and phencyclidine selectively blocked excitation by N-methyl-aspartate (NMA) with little effect on excitation by...

DOI: 10.1111/j.1476-5381.1983.tb11031.x Ketamine Phencyclidine Kainate receptor Renshaw cell +7

A behavioural and biochemical study in rats of 5-hydroxytryptamine receptor agonists and antagonists, with observations on structure-activity requirements for the agonists.

British Journal of Pharmacology July 1, 1981 A R Green, J E Hall, A R Rees 88 citations

1 The effect of the putative 5-hydroxytryptamine (5-HT) receptor antagonists, methysergide, methergoline, mianserin, cyproheptadine, cinanserin (all at 10 mg/kg), methiothepin (5 mg/kg) and (-)-propranolol (20 mg/kg) on the behavioural responses to tranylcypromine (10 mg/kg) followed 30 min later by L-tryptophan (100 mg/kg) was examined.2 Methysergide, methergoline, methiothepin and...

DOI: 10.1111/j.1476-5381.1981.tb16806.x Full text

THE INTEGRITY OF THE SOCIAL HIERARCHY IN MICE FOLLOWING ADMINISTRATION OF PSYCHOTROPIC DRUGS

British Journal of Pharmacology November 1, 1980 V. P. Poshivalov 23 citations

Mice in small groups develop a despotic type of social hierarchy, a feature of which is to resist alteration through the medium of psychotropic drugs. This makes a rapid pharmacologically induced change in the social hierarchy impossible. Patrolling the territory and a certain level of social interaction are both critical factors in maintaining the phenomenon of inertia in the social hierarchy....

DOI: 10.1111/j.1476-5381.1980.tb08712.x Hierarchy Aggression Diazepam Pharmacology +1

BEHAVIOURAL CHANGES INDUCED BY N,N‐DIMETHYLTRYPTAMINE IN RODENTS

British Journal of Pharmacology May 1, 1980 P. Jenner, C.d. Marsden, C.m. Thanki 38 citations

N,N‐Dimethyltryptamine (DMT) in pargyline pretreated rodents induced a dose‐dependent behavioural syndrome consisting of hyperactivity, prostration and hindlimb abduction, mild tremor, Straub tail, retropulsion and jerking. In rats pretreated with pargyline, the behavioural syndrome induced by DMT differed from that induced by l‐tryptophan or quipazine, in the lack of forepaw treading and...

DOI: 10.1111/j.1476-5381.1980.tb10884.x

BACKWARD WALKING AND CIRCLING: BEHAVIOURAL RESPONSES INDUCED BY DRUG TREATMENTS WHICH CAUSE SIMULTANEOUS RELEASE OF CATECHOLAMINES AND 5‐HYDROXYTRYPTAMINE

British Journal of Pharmacology August 1, 1979 G. Curzon, J.c.r. Fernando, Andrew J. Lees 66 citations

The roles of catecholamine and 5‐hydroxytryptamine (5‐HT) release in mediating backward walking and circling were studied in rats. These behaviours occurred in animals given 15mg/kg intraperitoneally of (+)‐amphetamine (which predominantly releases catecholamines) or either p ‐chloroamphetamine or fenfluramine (which predominantly release 5‐HT). They also occurred when smaller doses of...

DOI: 10.1111/j.1476-5381.1979.tb13696.x Serotonin Fenfluramine Licking Dextroamphetamine +7

SHAPE CHANGE OF BLOOD PLATELETS—A MODEL FOR CEREBRAL 5‐HYDROXYTRYPTAMINE RECEPTORS?

British Journal of Pharmacology April 1, 1979 Martin Graf, A. Pletscher 45 citations

In blood platelets of rabbits isolated by a stractan gradient and incubated in a protein‐poor medium, tryptamine, 5‐hydroxytryptamine (5‐HT) and derivatives, quipazine and mescaline caused a shape change. This shape change was inhibited by low concentrations of methysergide. The most potent antagonists of the 5‐HT‐induced shape change included ergoline derivatives and neuroleptic drugs, which...

DOI: 10.1111/j.1476-5381.1979.tb07870.x Serotonin Platelet Receptor

POTENTIATION BY DESIPRAMINE OF NEURONAL RESPONSES TO MESCALINE

British Journal of Pharmacology May 1, 1976 Paul Bevan, C. M. Bradshaw, E. Szabadi 4 citations

The effect of desipramine on responses of single cortical neurones to mescaline was studied by the microelectrophoretic technique. Both potentiation and antagonism of responses to mescaline by desipramine were observed. The antagonism may be related to the α‐adrenolytic action of desipramine. The potentiation is unlikely to reflect the uptake blocking action of desipramine, since desipramine...

DOI: 10.1111/j.1476-5381.1976.tb07666.x Mescaline Desipramine Long-term potentiation Antagonism +1

A COMPARISON OF THE EFFECT OF MESCALINE ON ACTIVITY AND EMOTIONAL DEFAECATION IN SEVEN STRAINS OF MICE

British Journal of Pharmacology September 1, 1975 Ian E. Lush 13 citations

Mescaline hemi‐sulphate (35 mg/kg body weight) was injected intraperitoneally into male mice ( Mus musculus ) from seven genetically diverse laboratory strains. The effect of mescaline was found by comparison of the emotional defaecation and open field activity of mice after mescaline injection with the performance of the same mice after a subsequent saline (0.9% w/v NaCl solution) control...

DOI: 10.1111/j.1476-5381.1975.tb07621.x Mescaline Saline Open field Body weight +1

REVERSAL LEARNING ENHANCED BY LYSERGIC ACID DIETHYLAMIDE (LSD): CONCOMITANT RISE IN BRAIN 5‐HYDROXYTRYPTAMINE LEVELS

British Journal of Pharmacology November 1, 1974 Alan R. King, Ian L. Martin, Kathleen Melville 38 citations

Small doses of lysergic acid diethylamide (LSD) (12.5–50 μg/kg) consistently facilitated learning of a brightness discrimination reversal. 2‐Bromo‐lysergic acid diethylamide (BOL‐148), a structural analogue of LSD, with similar peripheral anti‐5‐hydroxytrypamine activity but no psychotomimetic properties, had no effect in this learning situation at a similar dose (25 μg/kg). LSD, but not...

DOI: 10.1111/j.1476-5381.1974.tb08611.x Lysergic acid diethylamide Serotonin Concomitant Pharmacology +1

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