5-Methoxy-N,N-dimethyltryptamine-induced analgesia is blocked by alpha-adrenoceptor antagonists in rats.
T Archer, W Danysz, G Jonsson, B G Minor, C Post
British Journal of Pharmacology October 1, 1986 DOI: 10.1111/j.1476-5381.1986.tb10259.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | Prazosin phentolamine yohimbine 5-methoxy-N N-dimethyltryptamine (5-MeODMT) |
| Topics | 5-MeO-DMT DMT |
| Citations | 16 |
| Key findings | Intrathecal alpha-2 adrenoceptor antagonists block or attenuate 5-MeODMT-induced analgesia in rats, demonstrating a functional spinal interaction between alpha-2 adrenoceptors and serotonin agonist-induced pain relief. |
Abstract
The effects of the alpha-adrenoceptor antagonists prazosin, phentolamine and yohimbine upon 5-methoxy-N,N-dimethyltryptamine (5-MeODMT)-induced analgesia were tested in the hot-plate, tail-flick and shock-titration tests of nociception with rats. Intrathecally injected yohimbine and phentolamine blocked or attenuated the analgesia produced by systemic administration of 5-MeODMT in all three nociceptive tests. Intrathecally administered prazosin attenuated the analgesic effects of 5-MeODMT in the hot-plate and tail-flick tests, but not in the shock titration test. Intrathecal yohimbine showed a dose-related lowering of pain thresholds in saline and 5-MeODMT-treated animals. Phentolamine and prazosin produced normal dose-related curves in the hot-plate test and biphasic effects in the shock titration and tail-flick tests. These results demonstrate a functional interaction between alpha 2-adrenoceptors and 5-HT agonist-induced analgesia at a spinal level in rats.