POTENTIATION BY DESIPRAMINE OF NEURONAL RESPONSES TO MESCALINE
Paul Bevan, C. M. Bradshaw, E. Szabadi
British Journal of Pharmacology May 1, 1976 DOI: 10.1111/j.1476-5381.1976.tb07666.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Single cortical neurones |
| Interventions | Desipramine Mescaline |
| Topics | Mescaline |
| Keywords | Desipramine Long-term potentiation Antagonism Pharmacology |
| Citations | 4 |
| Key findings | Desipramine both potentiates and antagonizes cortical neuronal responses to mescaline, with potentiation likely due to a post-synaptic action. |
Abstract
The effect of desipramine on responses of single cortical neurones to mescaline was studied by the microelectrophoretic technique. Both potentiation and antagonism of responses to mescaline by desipramine were observed. The antagonism may be related to the α‐adrenolytic action of desipramine. The potentiation is unlikely to reflect the uptake blocking action of desipramine, since desipramine does not block the uptake of mescaline in the cerebral cortex. It is suggested that the potentiation may be due to a post‐synaptic action of desipramine.
Comparable studies
Other experimental studies on mescaline, most cited first.
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|---|---|---|---|
| Enzymatic Formation of Psychotomimetic Metabolites from Normally Occurring Compounds Rabbit lung | 1961 | Experimental study | |
| PSYCHOTOMIMETICS, CLINICAL AND THEORETICAL CONSIDERATIONS: HARMINE, WIN-2299 AND NALLINE Schizophrenic patients | 1957 | Experimental study | |
| Phencyclidine, Lysergic Acid Diethylamide, and Mescaline: Cerebral Artery Spasms and Hallucinogenic Activity Isolated basilar and middle cerebral arteries | 1981 | Experimental study | |
| Acquired and Crossed Tolerance to Mescaline, LSD-25, and BOL-148 | 1959 | Experimental study | |
| Effects of Hallucinogenic and Tranquilizing Drugs on Serotonin Evoked Uterine Contractions. Uterus of spayed rat | 1956 | Experimental study |