BACKWARD WALKING AND CIRCLING: BEHAVIOURAL RESPONSES INDUCED BY DRUG TREATMENTS WHICH CAUSE SIMULTANEOUS RELEASE OF CATECHOLAMINES AND 5‐HYDROXYTRYPTAMINE
G. Curzon, J.c.r. Fernando, Andrew J. Lees
British Journal of Pharmacology August 1, 1979 DOI: 10.1111/j.1476-5381.1979.tb13696.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | Amphetamine fenfluramine levallorphan |
| Dose | 15 mg/kg amphetamine; 5 mg/kg amphetamine; 2-5 mg/kg p-chloroamphetamine; 5 mg/kg fenfluramine; 50 mg/kg levallorphan |
| Topics | Serotonin |
| Keywords | Fenfluramine Licking Dextroamphetamine P-chloroamphetamine Hallucinogen Endocrinology Catecholamine Dopaminergic Pharmacology Anesthesia |
| Citations | 66 |
| Key findings | Backward walking and circling in rats are mediated by simultaneous dopamine and serotonin release. |
Abstract
The roles of catecholamine and 5‐hydroxytryptamine (5‐HT) release in mediating backward walking and circling were studied in rats. These behaviours occurred in animals given 15mg/kg intraperitoneally of (+)‐amphetamine (which predominantly releases catecholamines) or either p ‐chloroamphetamine or fenfluramine (which predominantly release 5‐HT). They also occurred when smaller doses of (+)‐amphetamine (5mg/kg) and either p ‐chloroamphetamine (2–5 mg/kg) or fenfluramine (5 mg/kg) were given together. Characteristic dopamine‐dependent behaviours (rearing, licking, gnawing) resulting from (+)‐amphetamine injection were greatly reduced by p ‐chloroamphetamine or fenfluramine. Characteristic 5‐HT‐dependent behaviours (wet dog shake, hind limb abduction) resulting from injection of either p ‐chloroamphetamine or fenfluramine were unaffected by (+)‐amphetamine. Fragmentary backward walking and circling resulting from levallorphan injection (50 mg/kg s.c.) were decreased by (+)‐amphetamine at low dosage. Results in general strengthen previous evidence that backward walking and circling are mediated by simultaneous dopamine and 5‐HT release. The possible relevance of the above findings to hallucinogenic activity, amphetamine psychosis, schizophrenia and abnormal movements due to l ‐DOPA treatment is discussed.
Comparable studies
Other preclinical and animal studies on serotonin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo Mice | 2021 | Observational cohort | |
| Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. Rats (implied by typical neurochemical study context) | 1987 | Experimental study | |
| Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors In vitro and in vivo (rodent) models | 2023 | Experimental study | |
| 3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites. Rat brain | 1987 | Animal experiment | |
| Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs Human and mouse dopamine, norepinephrine, and serotonin transporters expressed in cells | 2006 | In vitro laboratory study |
Citations in the library
Cited by 2
- 5‐HT loss in rat brain following 3, 4‐methylenedioxymethamphetamine (MDMA), p‐chloroamphetamine and fenfluramine administration and effects of chlormethiazole and dizocilpine British Journal of Pharmacology March 1, 1993
- Increased sensitivity to psychomotor effects of ketamine enantiomers in the Wistar-Kyoto depression model. Journal of Psychiatric Research April 1, 2025