Aisling Lavelle

Investigation of the prejunctional α2‐adrenoceptor mediated actions of MDMA in rat atrium and vas deferens

British Journal of Pharmacology November 1, 1999 Aisling Lavelle, Valerie Honner, James R. Docherty 55 citations

We have investigated the effects of methylenedioxymethamphetamine (MDMA, ‘ecstasy’) on peripheral noradrenergic neurotransmission in the rat. In rat atrial slices pre‐incubated with [ 3 H]‐noradrenaline and in the presence of desipramine (1 μ M ) to prevent effects of MDMA on basal outflow of tritium, MDMA (10 μ M ) significantly inhibited the release of tritium evoked by short trains of six...