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Ian E. Lush

2 papers in the library · 15 citations · publishing 1975

Papers

A COMPARISON OF THE EFFECT OF MESCALINE ON ACTIVITY AND EMOTIONAL DEFAECATION IN SEVEN STRAINS OF MICE

British Journal of Pharmacology September 1, 1975 Ian E. Lush 13 citations

In male mice from seven genetically diverse laboratory strains, mescaline (35 mg/kg) inhibited emotional defecation and stimulated open field activity in five strains (A2G, C3H/He, C57BR/cd, CBA/Cam, F/St) but not in two others (ICFW, Schneider). The degree of emotional defecation under saline control correlated positively with mescaline's inhibitory effect. Pre-treatment with tranylcypromine did not alter emotional defecation or mescaline's inhibition of it.

DOI: 10.1111/j.1476-5381.1975.tb07621.x (opens in new tab) Mescaline Saline Open field Body weight +3

A relationship between hexobarbitone sleeping time and susceptibility to mescaline in mice from different strains

Psychopharmacology January 1, 1975 Ian E. Lush 2 citations

Male mice from seven inbred strains (A2G, C57BR, C3H, F/st, CBA, ICFW, and Schneider) were tested for hexobarbitone sleeping time. The same strains had previously been tested for the inhibitory effect of mescaline on emotional defecation. A strong correlation between the two measures across strains was found, which was unexpected theoretically and may have important implications for pharmacogenetics.

DOI: 10.1007/bf00429260 (opens in new tab) Mescaline Psychology Correlation Biology