Behavioural evidence for a functional interaction between central 5-HT2 and 5-HT1A receptors.
British Journal of Pharmacology August 1, 1990 L I Backus, T Sharp, D G Grahame-Smith
1. The possibility of 5-HT2 receptor modulation of central 5-HT1A receptor function has been examined using the 5-hydroxytryptamine (5-HT) behavioural syndrome induced by 5-HT1A receptor active drugs in rats. 2. The 5-HT2/5-HTIC antagonist ritanserin (0.1-2 mg kg-1) increased the 5-HT behavioural syndrome induced by submaximally effective doses of 8-hydroxy-2-(di-n-propylamino)tetralin...