A COMPARISON OF THE EFFECT OF MESCALINE ON ACTIVITY AND EMOTIONAL DEFAECATION IN SEVEN STRAINS OF MICE
British Journal of Pharmacology September 1, 1975 DOI: 10.1111/j.1476-5381.1975.tb07621.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Male mice from seven genetically diverse laboratory strains |
| Interventions | Saline control Tranylcypromine |
| Dose | Mescaline hemi-sulphate 35 mg/kg, Tranylcypromine 20 mg/kg |
| Measures | Emotional defaecation, Open field activity |
| Topics | Mescaline |
| Keywords | Saline Open field Body weight Pharmacology |
| Citations | 13 |
| Key findings | Mescaline inhibited emotional defecation and stimulated open field activity in five of seven mouse strains, with a positive relationship between baseline emotional defecation and mescaline's inhibitory effect. |
Abstract
Mescaline hemi‐sulphate (35 mg/kg body weight) was injected intraperitoneally into male mice ( Mus musculus ) from seven genetically diverse laboratory strains. The effect of mescaline was found by comparison of the emotional defaecation and open field activity of mice after mescaline injection with the performance of the same mice after a subsequent saline (0.9% w/v NaCl solution) control injection. In strains A2G, C3H/He, C57BR/cd, CBA/Cam and F/St, mescaline inhibited emotional defaecation and stimulated open field activity. These effects did not occur in strains ICFW and Schneider. A positive relationship was found between the degree of emotional defaecation characteristic of each strain in the saline control experiment and the inhibitory effect of mescaline on emotional defaecation. Pre‐treatment of mice with tranylcypromine (20 mg/kg body weight, i.p.) had no effect on emotional defaecation or on its inhibition by mescaline.
Comparable studies
Other preclinical and animal studies on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species. C57BL/6J mice | 2020 | Experimental study with dose-response experiments | |
| Brain mechanisms of hallucinogens and entactogens Humans and rats | 2001 | Review | |
| Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology Zebrafish (Danio rerio) | 2012 | Experimental study | |
| Lysergic Acid Diethylamide- and Mescaline-Induced Attenuation of the Effect of Punishment in the Rat Rats | 1976 | Experimental study | |
| Dihydrobenzofuran Analogues of Hallucinogens. 3. Models of 4-Substituted (2,5-Dimethoxyphenyl)alkylamine Derivatives with Rigidified Methoxy Groups Rats (trained to discriminate saline from LSD tartrate) and rat cortical and... | 1996 | In vivo drug discrimination assay and in vitro radioligand binding assay |
Citations in the library
Cited by 5
- Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology Progress in Neuro-Psychopharmacology and Biological Psychiatry January 10, 2012
- A relationship between hexobarbitone sleeping time and susceptibility to mescaline in mice from different strains Psychopharmacology 1975
- Safety and Efficacy of Monoamine Oxidase Inhibitors in Patients Who Use Psychoactive Substances: Potential Drug Interactions and Substance Use Disorder Treatment Data. CNS Drugs January 17, 2026
- Estudo do perfil genotóxico, citotóxico, neurocomportamental e bioquímico da ayahuasca em ratos Wistar tratados com dose única November 25, 2014
- Psychotomimetics potentiate locomotor hyperactivity induced by dopaminergic drugs. Pharmacology, Biochemistry, and Behavior November 1979