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Benjamin J. B. Bréant

5 papers in the library · 50 citations · publishing 2021-2026

Papers

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Vigilance state dissociation induced by 5-MeO-DMT in mice.

Commun Biol January 5, 2026 Benjamin J. B. Bréant, José Prius-Mengual, Alexander Andrews et al. 1 citation

Psychedelics lead to profound changes in subjective experience and behaviour, which are typically conceptualised in psychological terms rather than corresponding to an altered brain state or a distinct state of vigilance. Here, we performed chronic electrophysiological recordings from the neocortex concomitant with pupillometry in freely moving adult male mice following an injection of a...

Vigilance state dissociation induced by 5-MeO DMT in mice

Research Square May 6, 2025 Benjamin J. B. Bréant, José Prius-Mengual, Alexander Andrews et al.

Abstract Psychedelics lead to profound changes in subjective experience and behaviour, which are typically conceptualised in psychological terms rather than corresponding to an altered brain state or a distinct state of arousal. Here, we performed chronic electrophysiological recordings from the neocortex concomitant with pupillometry in freely moving adult male mice following an injection of a...

Sleep-like state during wakefulness induced by psychedelic 5-MeO-DMT in mice

bioRxiv (Cold Spring Harbor Laboratory) December 11, 2022 Benjamin J. B. Bréant, José Prius-Mengual, David M. Bannerman et al. 5 citations preprint

Abstract Psychedelics lead to profound changes in subjective experience and behaviour, which are typically conceptualised in psychological terms rather than corresponding to an altered brain state or a distinct state of arousal. Here, we performed chronic electrophysiological recordings from the cortex concomitant with pupillometry in freely moving adult male mice following an injection of a...

Psilocin acutely alters sleep-wake architecture and cortical brain activity in laboratory mice

Translational Psychiatry February 23, 2022 Trevor Sharp, Christopher W. Thomas, Cristina Blanco-Duque et al. 40 citations

Abstract Serotonergic psychedelic drugs, such as psilocin (4-hydroxy-N,N-dimethyltryptamine), profoundly alter the quality of consciousness through mechanisms which are incompletely understood. Growing evidence suggests that a single psychedelic experience can positively impact long-term psychological well-being, with relevance for the treatment of psychiatric disorders, including depression. A...

Psilocin acutely disrupts sleep and affects local but not global sleep homeostasis in laboratory mice

bioRxiv Preprint Server February 16, 2021 Christopher W. Thomas, Cristina Blanco-Duque, Benjamin J. B. Bréant et al. 4 citations preprint

Serotonergic psychedelic drugs, such as psilocin (4-hydroxy-N,N-dimethyltryptamine), profoundly alter the quality of consciousness through mechanisms which are incompletely understood. Growing evidence suggests that a single psychedelic experience can positively impact long-term psychological well-being, with relevance for the treatment of psychiatric disorders, including depression. A...