Global Increases in Brain Glucose Metabolism Following Acute N,N-Dimethyltryptamine and Harmine Administration in Healthy Volunteers: An [¹⁸F]FDG-PET Study
Klemens Egger, Robert Bozsak, Helena Aicher, Hasan Sari, Sandra N. Poetzsch, Axel Rominger, Chantal Martin-Soelch, Dario Dornbierer, Boris B. Quednow, Milan Scheidegger, Paul Cumming
Research Square July 27, 2025 DOI: 10.21203/rs.3.rs-7099164/v1 (opens in new tab)
Summary
AI-generated from the abstractIn healthy volunteers, acute administration of N,N-dimethyltryptamine (DMT) combined with harmine produces global increases in brain glucose metabolism, as measured by [¹⁸F]FDG-PET. This suggests that the compound combination broadly energizes brain activity rather than acting on isolated regions. The findings indicate a neurobiological basis for the altered states of consciousness and mood enhancement reported with these psychoactive compounds, supporting further investigation into their therapeutic potential.
Study at a glance
| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Sample size | 14 |
| Population | Healthy volunteers |
| Interventions | N N-Dimethyltryptamine Harmine |
| Topics | 5-MeO-DMT |
| Keywords | Psychoactive compounds n Harmine Brain activity Energize your brain |
| Citations | 1 |
| Key finding | Acute administration of N,N-dimethyltryptamine and harmine globally increases brain glucose metabolism in healthy volunteers. |
Abstract
Global Increases in Brain Glucose Metabolism Following Acute N,N-Dimethyltryptamine and Harmine Administration in Healthy Volunteers: An [¹⁸F]FDG-PET Study