Psychological Medicine
May 4, 2023
Giulia Trotta, Victoria Rodriguez, Diego Quattrone et al.
Abstract Background Childhood adversity and cannabis use are considered independent risk factors for psychosis, but whether different patterns of cannabis use may be acting as mediator between adversity and psychotic disorders has not yet been explored. The aim of this study is to examine whether cannabis use mediates the relationship between childhood adversity and psychosis. Methods Data were...
Psychiatry and Clinical Neurosciences
April 18, 2023
Lucy Chester, L. Valmaggia, M. Kempton et al.
Evidence for case–control studies suggests that cannabis use is a risk factor for the development of psychosis. However, there have been limited prospective studies and the direction of this association remains controversial. The primary aim of the present study was to examine the association between cannabis use and the incidence of psychotic disorders in people at clinical high risk of...
Translational Psychiatry
August 10, 2021
Diego Quattrone, Ulrich Reininghaus, A. Richards et al.
Diagnostic categories do not completely reflect the heterogeneous expression of psychosis. Using data from the EU-GEI study, we evaluated the impact of schizophrenia polygenic risk score (SZ-PRS) and patterns of cannabis use on the transdiagnostic expression of psychosis. We analysed first-episode psychosis patients (FEP) and controls, generating transdiagnostic dimensions of psychotic symptoms...
Psychological Medicine
July 1, 2021
Annemarie C J Köhne, Jim van Os
Precision psychiatry is currently described as an approach that would bring significant advance to psychiatric clinical practice. Theaim of this article is to investigate Precision Psychiatry's promise for the future; should we substantially invest in this new approach? Thearticle is based on a review of the literature and reports a conceptual analysis. A critical examination of Precision...
Schizophrenia Bulletin
March 8, 2021
Jim van Os, L. Pries, M. Ten Have et al.
Abstract Hypotheses about the link between cannabis use and psychosis apply to the within-person level but have been tested mostly at the between-person level. We used a within-person design, in which a person serves as his own control, thus removing the need to consider confounding by any fixed (genetic and nongenetic) characteristic to study the prospective association between cannabis use...
Psychological Medicine
March 18, 2020
Diego Quattrone, Laura Ferraro, Giada Tripoli et al.
89 citations
Abstract Background Daily use of high-potency cannabis has been reported to carry a high risk for developing a psychotic disorder. However, the evidence is mixed on whether any pattern of cannabis use is associated with a particular symptomatology in first-episode psychosis (FEP) patients. Method We analysed data from 901 FEP patients and 1235 controls recruited across six countries, as part of...
PLoS One
June 10, 2016
Dina Collip, Nicole Geschwind, Frenk Peeters et al.
ContextParanoia embodies altered representation of the social environment, fuelling altered feelings of social acceptance leading to further mistrust. Mindfulness-based cognitive therapy (MBCT) may relieve paranoia and reduce its impact on social acceptance.ObjectiveTo determine whether MBCT alters momentary feeling of paranoia and social acceptance in daily life.DesignRandomized controlled...
PLoS One
August 23, 2013
T. Batink, Frenk Peeters, Nicole Geschwind et al.
Mindfulness based cognitive therapy (MBCT) is a non-pharmacological intervention to reduce current symptoms and to prevent recurrence of major depressive disorder. At present, it is not well understood which underlying mechanisms during MBCT are associated with its efficacy. The current study (n = 130) was designed to examine the roles of mindfulness skills, rumination, worry and affect, and...
Psychological Medicine
October 1, 2011
R. Kuepper, J. Van Os, R. Lieb et al.
BackgroundCannabis use is considered a component cause of psychotic illness, interacting with genetic and other environmental risk factors. Little is known, however, about these putative interactions. The present study investigated whether an urban environment plays a role in moderating the effects of adolescent cannabis use on psychosis risk.MethodProspective data (n=1923, aged 14–24 years at...
Journal of Consulting and Clinical Psychology
July 18, 2011
Nicole Geschwind, Frenk Peeters, Marjan Drukker et al.
440 citations
OBJECTIVE: To examine whether mindfulness-based cognitive therapy (MBCT) increases momentary positive emotions and the ability to make use of natural rewards in daily life. METHOD: Adults with a life-time history of depression and current residual depressive symptoms (mean age = 43.9 years, SD = 9.6; 75% female; all Caucasian) were randomized to MBCT (n = 64) or waitlist control (CONTROL; n =...
BMJ
March 1, 2011
Rebecca Kuepper, Jim van Os, R. Lieb et al.
307 citations
OBJECTIVE: To determine whether use of cannabis in adolescence increases the risk for psychotic outcomes by affecting the incidence and persistence of subclinical expression of psychosis in the general population (that is, expression of psychosis below the level required for a clinical diagnosis). DESIGN: Analysis of data from a prospective population based cohort study in Germany (early...
The British Journal of Psychiatry
May 31, 2010
Cécile Henquet, Jim van Os, Rebecca Kuepper et al.
124 citations
BACKGROUND: Little is known about the experiential dynamics of the interaction between cannabis and vulnerability to psychosis. AIMS: To examine the effects of cannabis on psychotic symptoms and mood in patients with psychosis and healthy controls. METHOD: Patients with a psychotic disorder (n = 42) and healthy controls (n = 38) were followed in their daily lives using a structured...
European Psychiatry
2009
Rebecca Kuepper, Inez Myin-Germeys, M. Konings et al.
2 citations
Frequent use of cannabis has been associated with poor outcome in patients with psychosis or schizophrenia, and research has become more and more interested in the question whether cannabis may actually cause psychosis or schizophrenia. Since only a minority of cannabis users eventually develops psychosis or schizophrenia, cannabis is suggested to be a component cause, potentially interacting...
Psychological Medicine
April 1, 2007
Audrey Cougnard, Machteld Marcelis, Inez Myin-Germeys et al.
Background. Research suggests that low-grade psychotic experiences in the general population are a common but transitory developmental phenomenon. Using two independent general population samples, the hypothesis was examined that common, non-clinical developmental expression of psychosis may become abnormally persistent when synergistically combined with developmental exposures that may impact...
European Psychiatry
June 1, 2005
Anton Grech, Jim Van Os, Peter B. Jones et al.
AbstractPurposeTo test the hypothesis that recent onset psychotic patients who use cannabis will have psychotic symptoms that are more severe and more persistent than those who do not use cannabis.Subjects and methodsWe carried out a 4-year follow-up study of a cohort of 119 patients with recent onset of psychosis. The patients were divided into four groups according to duration of cannabis...
Addiction
October 1, 2004
N. C. Stefanis, P. Delespaul, C. Henquet et al.
ABSTRACTAims To investigate the effect of exposure to cannabis early in adolescence on subclinical positive and negative symptoms of psychosis.Design Cross‐sectional survey in the context of an ongoing cohort study.Setting Government‐supported general population cohort study.Participants A total of 3500 representative 19‐year olds in Greece.Measurements Subjects filled in the 40‐item Community...