Psychiatry and Clinical Neurosciences
April 18, 2023
Lucy Chester, Lucia Valmaggia, Matthew J. Kempton et al.
Evidence for case–control studies suggests that cannabis use is a risk factor for the development of psychosis. However, there have been limited prospective studies and the direction of this association remains controversial. The primary aim of the present study was to examine the association between cannabis use and the incidence of psychotic disorders in people at clinical high risk of...
Translational Psychiatry
April 21, 2020
Musa Sami, Amanda Worker, Marco Colizzi et al.
AbstractThe associative striatum, an established substrate in psychosis, receives widespread glutamatergic projections. We sought to see if glutamatergic indices are altered between early psychosis patients with and without a history of cannabis use and characterise the relationship to grey matter. 92 participants were scanned: Early Psychosis with a history of cannabis use (EPC = 29); Early...
Journal of Neuroscience
November 19, 2018
Anthony S. Gabay, Matthew J. Kempton, James Gilleen et al.
40 citations
Social decision-making is fundamental for successful functioning and can be affected in psychiatric illness and by serotoninergic modulation. The Prisoner's Dilemma is the archetypal paradigm to model cooperation and trust. However, the effect of serotonergic enhancement is poorly characterized, and its influence on the effect of variations in opponent behavior unknown. To address this, we...
Schizophrenia Bulletin
August 6, 2018
Ulrich Reininghaus, Margaret Oorschot, Steffen Moritz et al.
33 citations
Cognitive models of psychosis posit that reasoning biases are an important mechanism contributing to the formation of psychotic symptoms, in part through transforming anomalous experiences of aberrant salience into frank psychotic symptoms. This study aimed to investigate the interplay of liberal acceptance (LA) bias, which is a specific type of reasoning bias, and momentary aberrant salience...
Schizophrenia Bulletin
February 1, 2016
Ulrich Reininghaus, Matthew J. Kempton, Lucia Valmaggia et al.
315 citations
While contemporary models of psychosis have proposed a number of putative psychological mechanisms, how these impact on individuals to increase intensity of psychotic experiences in real life, outside the research laboratory, remains unclear. We aimed to investigate whether elevated stress sensitivity, experiences of aberrant novelty and salience, and enhanced anticipation of threat contribute...