Frontiers in Psychiatry
June 20, 2023
Johannes T. Reckweg, Cees van Leeuwen, Cécile Henquet et al.
86 citations
Background Treatment-resistant depression (TRD) is a substantial public health burden, but current treatments have limited effectiveness. The aim was to investigate the safety and potential antidepressant effects of the serotonergic psychedelic drug 5-MeO-DMT in a vaporized formulation (GH001) in adult patients with TRD. Methods The Phase 1 part ( n = 8) of the trial investigated two single...
Psychological Medicine
October 1, 2011
R. Kuepper, J. Van Os, R. Lieb et al.
BackgroundCannabis use is considered a component cause of psychotic illness, interacting with genetic and other environmental risk factors. Little is known, however, about these putative interactions. The present study investigated whether an urban environment plays a role in moderating the effects of adolescent cannabis use on psychosis risk.MethodProspective data (n=1923, aged 14–24 years at...
BMJ
March 1, 2011
Rebecca Kuepper, Jim van Os, R. Lieb et al.
307 citations
OBJECTIVE: To determine whether use of cannabis in adolescence increases the risk for psychotic outcomes by affecting the incidence and persistence of subclinical expression of psychosis in the general population (that is, expression of psychosis below the level required for a clinical diagnosis). DESIGN: Analysis of data from a prospective population based cohort study in Germany (early...
The British Journal of Psychiatry
September 30, 2010
Cécile Henquet, Rebecca Kuepper
16 citations
A recent study by Morgan and colleagues found that cannabidiol attenuates the acute cognitive effects of delta-9-tetrahydrocannabinol (THC). This is of interest as THC has been associated with the detrimental effects of cannabis on mental health in at-risk users, and the potency of cannabis is increasing across Europe.
The British Journal of Psychiatry
May 31, 2010
Cécile Henquet, Jim van Os, Rebecca Kuepper et al.
124 citations
BACKGROUND: Little is known about the experiential dynamics of the interaction between cannabis and vulnerability to psychosis. AIMS: To examine the effects of cannabis on psychotic symptoms and mood in patients with psychosis and healthy controls. METHOD: Patients with a psychotic disorder (n = 42) and healthy controls (n = 38) were followed in their daily lives using a structured...
European Psychiatry
2009
Rebecca Kuepper, Inez Myin-Germeys, M. Konings et al.
2 citations
Frequent use of cannabis has been associated with poor outcome in patients with psychosis or schizophrenia, and research has become more and more interested in the question whether cannabis may actually cause psychosis or schizophrenia. Since only a minority of cannabis users eventually develops psychosis or schizophrenia, cannabis is suggested to be a component cause, potentially interacting...
Schizophrenia Bulletin
November 1, 2008
Cécile Henquet, Marta Di Forti, Paul D. Morrison et al.
Cannabis use is considered a contributory cause of schizophrenia and psychotic illness. However, only a small proportion of cannabis users develop psychosis. This can partly be explained by the amount and duration of the consumption of cannabis and by its strength but also by the age at which individuals are first exposed to cannabis. Genetic factors, in particular, are likely to play a role in...
Psychological Medicine
April 1, 2007
Audrey Cougnard, Machteld Marcelis, Inez Myin-Germeys et al.
Background. Research suggests that low-grade psychotic experiences in the general population are a common but transitory developmental phenomenon. Using two independent general population samples, the hypothesis was examined that common, non-clinical developmental expression of psychosis may become abnormally persistent when synergistically combined with developmental exposures that may impact...
Addiction
October 1, 2004
N. C. Stefanis, P. Delespaul, C. Henquet et al.
ABSTRACTAims To investigate the effect of exposure to cannabis early in adolescence on subclinical positive and negative symptoms of psychosis.Design Cross‐sectional survey in the context of an ongoing cohort study.Setting Government‐supported general population cohort study.Participants A total of 3500 representative 19‐year olds in Greece.Measurements Subjects filled in the 40‐item Community...