Influence of cannabis use on incidence of psychosis in people at clinical high risk
Lucy Chester, L. Valmaggia, M. Kempton, Edward Chesney, D. Oliver, Emily P. Hedges, Elise Klatsa, Daniel Ståhl, M. van der Gaag, Lieuwe de Haan, Barnaby Nelson, Patrick D. Mcgorry, G. Amminger, Anita Riecher‐rössler, Erich Studerus, R. Bressan, N. Barrantes-Vidal, Marie-Odile Krebs, B. Glenthøj, Merete Nordentoft, Stephan Ruhrmann, G. Sachs, P. McGuire, Philip Mcguire, Maria Calem, S. Tognin, G. Modinos, Eva Velthorst, T. Kraan, Daniëlla S. van Dam, Nadine Burger, Christos Pantelis, Athena Politis, J. Goodall, Stefan Borgwardt, A. Gadelha, Elisa Brietzke, G. Asevedo, E. Asevedo, A. Zugman, Tecelli Domínguez-Martínez, Anna Racioppi, T. Kwapil, Manel Monsonet, L. Hinojosa, M. Kazès, C. Daban, J. Bourgin, O. Gay, C. Mam‐Lam‐Fook, M. Krebs, D. Nordholm, L. Randers, K. Krakauer, L. Glenthøj, Dominika Gebhard, Julia Arnhold, J. Klosterkötter, I. Lasser, B. Winklbaur, Philippe Delespaul, Bart P. F. Rutten, Jim van Os
Psychiatry and Clinical Neurosciences April 18, 2023 DOI: 10.1111/pcn.13555 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Prospective cohort study Peer reviewed |
|---|---|
| Population | People at clinical high risk of psychosis |
| Topics | Cannabis |
| Key findings | Cannabis use is associated with a higher incidence of psychotic disorders and more persistent psychotic symptoms in people at clinical high risk for psychosis. |
Abstract
Evidence for case–control studies suggests that cannabis use is a risk factor for the development of psychosis. However, there have been limited prospective studies and the direction of this association remains controversial. The primary aim of the present study was to examine the association between cannabis use and the incidence of psychotic disorders in people at clinical high risk of psychosis. Secondary aims were to assess associations between cannabis use and the persistence of psychotic symptoms, and with functional outcome.