Stereotactic and Functional Neurosurgery
1963
M. Knoll, J Kugler, Oskar Höfer et al.
57 citations
The perception of patterns not resulting from viewing external objects but stimulated by cranial electrodes with pulse currents within the electroencephalographic frequency range (‘phosphenes’) has been investigated in earlier work. The experiments described in this paper were undertaken to observe in one subject effects of chemical stimulation (by mescaline, psilocybin and LSD) on...
American Journal of Physiology-Legacy Content
July 1, 1962
Peter K. Gessner, Irvine H. Page
64 citations
The effect of 5-methoxy-N:N-dimethyltryptamine on the conditioned avoidance response of trained rats was compared quantitatively, using a shuttle-box, with that of several substituted tryptamines and LSD-25. 5-Methoxy-N:N-dimethyltryptamine, at a dose level of 19 µm/kg, had a pronounced effect on the conditioned avoidance response, much more pronounced than that due to the known psychotomimetic...
Science
August 4, 1961
Julius Axelrod
183 citations
An enzyme has been found that N-methylates serotonin and tryptamine to psychotomimetic metabolites, bufotenine and N,N-dimethyltryptamine. This enzyme is highly localized in the rabbit lung and also N-methylates phenylethylamine derivatives such as tyramine, phenylethylamine, mescaline, and dopamine.
Archives of General Psychiatry
March 1, 1960
Arthur L. Chandler
77 citations
Our use of drug-facilitated psychotherapy has been to aid repressed material to become conscious and to increase insight. Any method or tool which facilitates these processes has the possibility of being a valuable psychotherapeutic tool. Certain drugs on which we have done research, such as mescaline, ALD-52, ibogaine, psilocybin, Ditran (N-ethyl-3-piperidyl cyclopentylphenyl glycolate HC1),...
Journal of Mental Science
October 1, 1958
J. C. Brengelmann, C. M. B. Pare, M. Sandler
31 citations
In the investigation described, the hypothesis was tested that 5-hydroxytryptamine (5HT) acts to reduce the psychological effects of lysergic acid diethylamide (LSD). The method was to inject 5-hydroxytryptophan (5HTP) prior to LSD and to compare the results of psychological tests performed after these injections. Placebo controls were used.
Annals of Internal Medicine
May 1, 1958
Nicholas T. Richards, Latasha Chapman, H Goodell et al.
16 citations
Case Reports1 May 1958LSD-LIKE DELIRIUM FOLLOWING INGESTION OF A SMALL AMOUNT OF ITS BROM ANALOG (BOL-148)NELSON RICHARDS, LORING F. CHAPMAN, HELEN GOODELL, HAROLD G. WOLFF, F.A.C.P.NELSON RICHARDSSearch for more papers by this author, LORING F. CHAPMANSearch for more papers by this author, HELEN GOODELLSearch for more papers by this author, HAROLD G. WOLFF, F.A.C.P.Search for more papers by...
British Journal of Pharmacology and Chemotherapy
September 1, 1957
William A. Krivoy
23 citations
Lysergic acid diethylamide (LSD) potentiated the response of guinea‐pig ileum to substance P but not to histamine. It also inhibited the disappearance of substance P when incubated with guinea‐pig brain extract but not when incubated with chymotrypsin. Eserine, morphine, mescaline, chlorpromazine, ergometrine, strychnine and 2 bromo‐LSD did not have this effect. Oxytocin was not destroyed by...
Archives of Neurology And Psychiatry
June 1, 1956
Bert E. Schwarz
49 citations
In a recent report concerning the reversibility by chlorpromazine of psychoses induced by means of mescaline andd-lysergic acid diethylamide (LSD-25), careful attention was given to the clinical and electroencephalographic changes.1Although the clinical changes of this reversal effect were immediate and striking, the conventional electroencephalographic changes were minimal, and it was...
Journal of Mental Science
April 1, 1954
R. A. Sandison, A. M. Spencer, J. D. A. Whitelaw
191 citations
D-lysergic acid diethylamide (LSD 25) was first prepared in 1938 by Stoll and Hofmann. It is the synthetic amide of d-lysergic acid with a secondary amine, diethylamine and belongs to the ergonovine group of ergot alkaloids all of which have lysergic acid as a base. After its ingestion in minute doses, it induces psychic states in which the subject becomes aware of repressed memories and other...
American Journal of Psychiatry
February 1, 1952
Paul H. Hoch, James P. Cattell, Harry H. Pennes
116 citations
The effects of mescaline and lysergic acid were studied in schizophrenic patients. It was found that physiological changes were produced in these patients and that their mental symptomatology was markedly aggravated. The observations made with the above-mentioned drugs on normal individuals were compared with those seen in schizophrenic patients. Mescaline and lysergic acid are drugs that...