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Encyclopedia of Life Sciences August 15, 2012 Katherine R. Bonson 5 citations
Abstract Hallucinogens constitute one of the oldest classes of drugs used by humanity, often in the context of spiritual practices. Classic hallucinogens such as lysergic acid diethylamide (LSD), psilocybin, N,N ‐dimethyltryptamine (DMT), mescaline and 2,5‐dimethoxy‐4‐methylamphetamine (DOM) produce complex psychological and physical effects, including perceptual changes, cognitive shifts in...
NeuroQuantology June 1, 2012 Ümit Sayın 17 citations
Altered states of consciousness induced by hallucinogens (H-ASC) is still a vaguely understood phenomenon. Taken the diverse psychological effects they exert, the main mechanism of action of hallucinogens; LSD, ibogaine, THC, PCP, MDMA, methamphetamine, mescaline, psilocybin and DMT, of which psychological effects are discussed in the article, are not properly understood and explained by the...
Drug and Alcohol Review May 21, 2012 Janine V. Olthuis, Christine Darredeau, Sean P. Barrett 79 citations
Abstract Introduction and Aims. Simultaneous polysubstance use (SPU) is a common phenomenon, yet little is known about its role in substance use initiation. Design and Methods. In the present study, 226 cannabis users completed structured interviews about their substance use history. For each substance ever used, participants provided details of their age of first use, their use in the...
Science Translational Medicine February 22, 2012 George A. Mashour
The psychedelic drug psilocybin uncouples the activity of key brain areas, providing insight into new therapies for psychiatric disorders.
Zurich Open Repository and Archive (University of Zurich) 2012 André Schmidt
Recent studies into the molecular, pharmacological and behavioral basis of psychotomimetics such as the glutamate N-methyl- D -aspartate receptor (NMDAR) antagonist ketamine and the mixed 5- hydroxytryptamine (5-HT) receptor agonist psilocybin in healthy human subjects suggest that both the glutamatergic and serotonergic system are implicated in the pathophysiolology of psychotic disorders such...
International Journal of Transpersonal Studies 2012 David Luke 35 citations
This paper investigates the relationship between psychoactive substances and so-called paranormal phenomena falling within the study of parapsychology. It is primarily concerned with extrasensory perception (ESP)—telepathy, precognition, and clairvoyance—as well as out-of-body experiences (OBEs) and near-death experiences (NDEs). Psychokinesis (PK), aura vision, encounter experiences, and sleep...
Seeing and Perceiving 2012 David Luke, Devin B. Terhune, Ross Friday 11 citations
The neurobiology of synaesthesia is receiving growing attention in the search for insights into consciousness, such as the binding problem. One way of decoding the neurocognitive mechanisms underlying this phenomenon is to investigate the induction of synaesthesia via neurochemical agents, as commonly occurs with psychedelic substances. How synaesthesia is affected by drugs can also help inform...
Psychiatric News December 16, 2011 Joan Arehart-Treichel
Even if ingesting the hallucinogen psilocybin can increase positive feelings of bliss or oneness with the universe, it is questionable whether such feelings represent authentic mystical experience or spiritual growth.
Humana Press eBooks August 26, 2011 Javed Khan, Thomas J. Kennedy, Donnell R. Christian 2 citations
Natural and synthetic analogs of tryptamine are introduced as a class of hallucinogenic drugs derived from indole. The forensic identification of psilocin, psilocybin, bufotenin, 5-methoxy-N,N-dimethyltryptamine (5MeODMT), 5-methoxy-N,N-diisopropyltryptamine (5MeODIPT, aka foxy methoxy), N,N-diethyltryptamine (DET), and alpha-ethyltryptamine (AET) is discussed. Structural formulas are provided...
Journal of Psychoactive Drugs July 1, 2011 Anette Kjellgren, Christophe Soussan 52 citations
The psychoactive substance 4-HO-MET (4-hydroxy-N-methyl-N-ethyltryptamine) with psychedelic qualities is one of many legal so-called Internet drugs. The aim of this qualitative study was to establish an understanding of what characterizes its recreational use. Very little is known about the effects of this substance. Twenty-five anonymous Swedish experience reports (from persons aged 18-30...