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Molecular Psychiatry August 11, 2026
Psychedelics and astrocytes: a hypothesis-driven perspective on neuro-glial integration, network plasticity, and neuroimmune reprogramming.
bioRxiv (Cold Spring Harbor Laboratory) August 10, 2026 Aedan O'Shea, Natasha L. Mason, Jacco Briede et al. preprint
Abstract Psilocybin acutely alters neurotrophic, neurochemical, and immune markers, but the relationships between these responses and circulating microRNAs (miRNAs), i.e. non-coding RNAs that regulate post-transcriptional gene expression, remain unclear. In a randomized, double-blind, placebo-controlled study of 62 healthy adults who received psilocybin (0.17 mg/kg) or placebo, we previously...
Journal of Affective Disorders August 10, 2026 Yves Martins Varela, Patrícia Cavalcanti-Ribeiro, Geovan Menezes de Sousa et al.
BACKGROUND: Ketamine is an effective rapid-acting treatment for treatment-resistant depression (TRD), producing antidepressant effects within hours of administration. Because it induces states of heightened neuroplasticity and psychological openness, psychotherapy may enhance its therapeutic effects. METHODS: This exploratory, nonrandomized, open-label clinical trial evaluated the adjunctive...
Psychological Medicine August 7, 2026 Igor Branchi
Psychiatric disorders are complex conditions involving multifactorial, nonlinear causal dynamics, which make effective treatment challenging. To address this complexity, a framework is proposed that distinguishes between types of causality: permissive causality, which pertains to factors affecting the likelihood of an outcome occurring, and instructive causality, which refers to factors shaping...
Frontiers in Human Neuroscience August 7, 2026 Tommaso Firaux, Paola Damiani, Marco Cavaglià
Building on the EMI framework that conceptualises consciousness, cognition, and behaviour as emergent phenomena arising from dynamic interactions among energy, mass, and information, this article extends the model into the educational domain by reframing learning as a resonance-based process within complex adaptive systems. While the initial formulation of EMI provided a scale-free biophysical...
Asclepius International Journal of Scientific Health Science August 7, 2026 Arthur Gomes Ferreira
A dependência da nicotina representa um dos principais desafios da saúde pública mundial, sendo responsável por elevadas taxas de morbimortalidade e associada ao desenvolvimento de doenças cardiovasculares, respiratórias e neoplásicas. Embora existam diferentes estratégias terapêuticas para a cessação do tabagismo, as elevadas taxas de recaída evidenciam a necessidade de novas abordagens...
Revista de Estudos Interdisciplinares August 6, 2026 Helena Victor Leite Panadés, Isadora Queiroz Graça, Maria Fernanda Vasconcelos Mascarenhas Clementino et al.
Introduction: Treatment-resistant depression (TRD) is characterized by the persistence of depressive symptoms following at least two adequate therapeutic trials with distinct classes of antidepressants. Given the limited efficacy of the traditional monoaminergic model and the high socioeconomic and functional burden of the disease, interventions with rapid mechanisms of action have become...
Artefactum August 6, 2026 Laura Alves Dutra, Anne Karolyne Alves Martins, Marina Camarão Oliveira et al.
Introduction:Treatment-resistant depression (TRD) is defined by the persistence of depressive symptoms despite at least two adequate trials with different classes of antidepressants. Limitations of traditional monoaminergic drugs have driven the search for rapid-acting, innovative interventions such as ketamine and electroconvulsive therapy (ECT), which target neuroplasticity and the...
Frontiers in Psychology August 5, 2026 Giancarlo Di Gennaro, A. Tomasini, Enrico Michele Salamone
Recent advances in theoretical physics suggest that time may exhibit a richer, potentially multidimensional structure, challenging classical linear conceptions. This Perspective develops a conceptual framework for understanding altered temporal experience in epilepsy, where seizures-driven by hypersynchronous neuronal activity and disrupted network synchronization-produce both clinical...
Brain Research Bulletin August 1, 2026 Barkha J. Yadav-Samudrala, Laith E. Sawaqed, Caitlin J. Huguely Wilkinson et al.
While combined antiretroviral therapy (cART) has transitioned HIV-1 into a manageable chronic condition, it fails to eradicate latent viral reservoirs in the central nervous system (CNS) that drive persistent neuroinflammation and synaptodendritic injury. Consequently, people living with human immunodeficiency virus type-1 (HIV-1) often utilize cannabis to manage neurological symptoms, yet the...